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142880-36-2
???:
?????
???(??):
?????
???:
Ilomastat
???(??):
CS-1405;SANTACRUZ;llomastat;IlloMastat;sc-203979A;galardin tm;Ilomastat, >=98%;GM 6001 Ilomastat;Ilomastat (GM 6001);Galardin CS 610
CBNumber:
CB11178927
???:
C20H28N4O4
??? ??:
388.46
MOL ??:
142880-36-2.mol
MSDS ??:
SDS

????? ??

??
1.228±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO ? 100% ???? ?????.
?? ?? (pKa)
9.16±0.20(Predicted)
??? ??
??? ??
??
???
??
Moisture Sensitive
???
??? ?? ?????? 1? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 3?? ?? ??? ? ????.
??? ?? ??
????
?? ????
InChIKey
NITYDPDXAAFEIT-DYVFJYSZSA-N
SMILES
CNC([C@@H](NC([C@@H](C(C)C)CC(NC)=O)=O)CC1=CNC2=CC=CC=C21)=O
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????? 22-24/25
WGK ?? 3
HS ?? 29339900
???? ??? 11 - Combustible Solids
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P501 ...? ??? / ??? ?? ???.

????? C??? ??, ??, ??

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Ilomastat is a metalloprotease inhibitor.

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A cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.

Biochem/physiol Actions

GM6001 promotes cardiovascular and hepatocellular function.

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