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2465-27-2
???:
???
???(??):
????;?????;???;C.I.Basic???2;?????;4,4'-(???????)??(N,N-???????) ???????????;ADC auramine O;Auramine n;Auramine o;Basic ??? 2;C.I. Basic ??? 2;????, 4,4'-?????????[N,N-????-, ????????? (1:1)
???:
AURAMINE O
???(??):
AURAMINE;BASIC YELLOW 2;Auramin;auamine;NSC4045;CI 41000;NSC 4045;NSC-4045;NSC47707;Conc. SFA
CBNumber:
CB1123098
???:
C17H22ClN3
??? ??:
303.83
MOL ??:
2465-27-2.mol
MSDS ??:
SDS

??? ??

???
>250 °C (dec.)(lit.)
?? ??
430kg/m3
?? ??
Inert atmosphere,Room Temperature
???
10g/L
?? ?? ??
41000
??? ??
??/??
?? ?? (pKa)
9.8, 10.7(at 25℃)
??
???~???
??????(pH)
6-7 (10g/l, H2O, 20℃)
pH ??
6.5
???
??? ???? ???
?? ??(λmax)
370 nm, 432 nm
ε (????)
≥12000 at 249-255nm in water at 0.005g/L
≥15000 at 367-373nm in water at 0.005g/L
≥36000 at 429-435nm in water at 0.005g/L
BRN
4030061
Henry's Law Constant
3.5×1010 mol/(m3Pa) at 25℃, HSDB (2015)
???
????. ?? ???? ???? ????.
??? ??? ??
Detecting bacteria; treatment of cancers,cardiovascular disease,diabetesassociated pain,mechanical allodynia,metabolic syndrome,protozoan infections in fish; targeted drug delivery; as fungal inhibitors
?? ??
?? ?? ??
???
???
InChI
1S/C17H21N3.ClH/c1-19(2)15-9-5-13(6-10-15)17(18)14-7-11-16(12-8-14)20(3)4;/h5-12,18H,1-4H3;1H
InChIKey
KSCQDDRPFHTIRL-UHFFFAOYSA-N
CAS ??????
2465-27-2(CAS DataBase Reference)
NIST
Aniline, 4,4'-(imidocarbonyl)bis-(n,n-dimethyl)-, hydrochloride(2465-27-2)
EPA
Auramine, monohydrochloride (2465-27-2)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T,Xn
?? ???? ?? 22-24-40-20/21/22
????? 36/37-45-36-22
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
RTECS ?? BY3675000
TSCA TSCA listed
HS ?? 3204 13 00
?? ?? 6.1
???? III
???? ??? 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 2
Carc. 2
Eye Irrit. 2
?? ?? ??? 2465-27-2(Hazardous Substances Data)
?? LD50 orally in Rabbit: 1000 mg/kg
???? ?? KE-04744
????(GHS): Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H351 ?? ??? ??? ??? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??) ??? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
H411 ??? ??? ?? ????? ??? ?? ????? ?? - ?? ?? 2
??????:
P201 ?? ? ?? ???? ?????.
P273 ???? ???? ???.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
0
2 0

??? C??? ??, ??, ??

??? ??

yellow powder

??

Certified for use by fluorescence microscopy in Churukian's modification of Truant's fluorescent method for acid fast bacilli on paraffin sections.

??

ChEBI: A hydrochloride obtained by combining 4,4'-carbonimidoylbis(N,N-dimethylaniline) with one molar equivalent of hydrogen chloride. A fluorescent stain for demonstrating acid fast organisms in a method similar to the Zieh Neelsen. It also can be used to make a fluorescent Schiff reagent.

?? ??

Yellow flakes or powder.

??? ?? ??

Insoluble in water.

?? ???

AURAMINE O is incompatible with strong oxidizing agents.

???

Probable carcinogen.

????

Flash point data for AURAMINE O are not available. AURAMINE O is probably combustible.

??? ??

Auramine is used industrially as a dye or dye intermediate for coloring textiles; paper, and leather. Also used as an antiseptic (a powerful antiseptic in ear and nose surgery, and treatment of gonorrhea) and fungicide. Human exposure to auramine occurs principally through skin absorption or inhalation of vapors. Low-level dermal exposure to the consumer may occur but would be limited to any migration of auramine from fabric, leather, or paper goods.

?? ??

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

It crystallises from EtOH as the hydrochloride and is very slightly soluble in CHCl3, UV: 434nm ( 370). The free base (carbinolamine) has m 136o (from *C6H6). [Goldacre & Phillips J Chem Soc 1724 1949, Conrad et al. Biochemistry 9 1540 1970, Beilstein 14 IV 256.]

? ???

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

??? ??

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incinerate in furnace with afterburner and scrubber.

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