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?? ??:: 88360-87-6

???:: ?????

???(??):: ?????

???:: amauromine

???(??):: WF-6237;FR-900220;amauromine;Antibiotic FR-900220;4'',5'':1',5']dipyrrolo[2,3-b:2',3'-b']diindole-7,15(5H,7aH)-dione;4a-bromo-8-methoxy-1,4a,5,10a-tetrahydropyrimido[5,4-b]quinoline-2,4,10(3h)-trione;(5aS,7aS,8aR,13aS,15aS,16aR)-8a,16a-Bis(1,1-dimethyl-2-propen-1-yl)-5a,8,8a,13,13a,15a,16,16a-octahydro-pyrazino[1'',2'':1,5;(5aS)-8aα,16aα-Bis(1,1-dimethyl-2-propenyl)-5aα,8,8a,13,13aα,15aβ,16,16a-octahydropyrazino[1'',2'':1,5:4'',5'':1',5']dipyrrolo[2,3-b:2',3'-b']diindole-7,15(5H,7aβH)-dione;4'',5'':1',5']dipyrrolo[2,3-b:2',3'-b']diindole-7,15(5H,7aH)-dione, 8a,16a-bis(1,1-dimethyl-2-propen-1-yl)-5a,8,8a,13,13a,15a,16,16a-octahydro-, (5aS,7aS,8aR,13aS,15aS,16aR)-

CBNumber:: CB11327574

???:: C32H36N4O2

??? ??:: 508.662

MOL ??:: 88360-87-6.mol

?? ?? 33

????? ??

?? ?: 689.9±55.0 °C(Predicted)

??: 1.28±0.1 g/cm3(Predicted)

?? ??: Store at -20°C

???: DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble

??? ??: ??

?? ?? (pKa): 3.26±0.60(Predicted)

??: ??

?? ? ?? ??

??	LD50 intraperitoneal in mouse: > 200mg/kg

????(GHS):

?? ?:

Warning

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P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P271	?? ?? ??? ? ?? ???? ?????.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P321	(…) ??? ???.
P330	?? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
3		0

????? C??? ??, ??, ??

??

Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB₁ that is selective for CB₁ (K_i = 178 nM; K_b = 66.6 nM) over CB₂, with no activity at CB₂ receptors at concentrations up to 10 μM. It is also an antagonist of GPR18 (IC₅₀ = 3.74 μM). Amauromine has vasodilatory activity.

????? ?? ?? ? ???

???

L-Tryptophan, N,1-bis[(1,1-dimethylethoxy)carbonyl]-, methyl ester

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???( 33)?? ??

???	??	???	??	?? ?	??
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????? ?? ??:

(R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE CYCLO(-LEU-GLY) 2-(3-PHENYL-PYRROLIDIN-1-YL)-ETHYLAMINE CHEMBRDG-BB 4012298 Piperazinone, 1-butyl- (9CI) CYCLO(-LEU-PRO) Pyrrolo[1,2-a]pyrazine, octahydro-3-isobutyl- (5CI) N-(1-METHYL-3-PHENYLPROPYL)-N-VALERAMIDE CYCLO(-GLY-PRO) amauromine 1H-Indol-2-amine 3-ISOBUTYL-6-METHYL-2,5-PIPERAZINEDIONE

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