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???? ??? ???
?? ??:
51264-14-3
???:
????
???(??):
????
???:
Amsacrine
???(??):
AMSA;CI-880;m-AMSA;C01553;Amekrin;Amsidyl;Amsakrin;AMSIDINE;Lamasine;SN 11841
CBNumber:
CB1236394
???:
C21H19N3O3S
??? ??:
393.46
MOL ??:
51264-14-3.mol

???? ??

???
230-240 °C
?? ?
563.0±60.0 °C(Predicted)
??
1.2205 (rough estimate)
???
1.6740 (estimate)
?? ??
2-8°C(protect from light)
???
DMSO? ???
??? ??
??
?? ?? (pKa)
8.55±0.10(Predicted)
??
Orange to red
CAS ??????
51264-14-3
IARC
2B (Vol. 76) 2000
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(UN No.) 3249
?? ?? 6.1(b)
???? III
?? ?? ??? 51264-14-3(Hazardous Substances Data)
?? LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov)
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H227 ??? ?? ??? ?? ?? 4 ?? P210, P280, P370+P378, P403+P235,P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
??????:
P210 ?·???·??·????? ????? - ?? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P370+P378 ?? ? ?? ?? ?? (Section 5. ??, ??? ????? ??? ???)?(?) ?????.
P403+P235 ??? ? ?? ?? ???? ???? ?????.
P501 ...? ??? / ??? ?? ???.

???? C??? ??, ??, ??

??

Amsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia which has failed primary treatment or become resistant. Its clinical use, however, is associated with significant neuro-, gastro- and hepatotoxicity.

??

Amsacrine (Amsidyl) is used as an Investigational drug.

??

ChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

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