ChemicalBook >?? ???? >?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,??????

?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,??????

?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,?????? ??? ???

?? ??:: 1013330-79-4

???:: ?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,??????

???(??):: ?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,??????

???:: CarbaMic acid, N-[[4-[[(4-aMino[1,1'-biphenyl]-3-yl)aMino]carbonyl]phenyl]Methyl]-, Methyl ester

???(??):: N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester;N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester;CarbaMic acid, N-[[4-[[(4-aMino[1,1'-biphenyl]-3-yl)aMino]carbonyl]phenyl]Methyl]-, Methyl ester

CBNumber:: CB12627657

???:: C22H21N3O3

??? ??:: 375.42

MOL ??:: 1013330-79-4.mol

?? ?? 11

?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,?????? ??

???: 172-174°C

?? ?: 532.2±50.0 °C(Predicted)

??: 1.261±0.06 g/cm3(Predicted)

?? ??: Refrigerator

???: DMSO(?? ???), ???(?? ???)

?? ?? (pKa): 11.65±0.46(Predicted)

??? ??: ??

??? ??: ??? ??

??: ???

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?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,?????? C??? ??, ??, ??

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Off-White Solid

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N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester is a biaryl benzamides that exhibit inhibitory selectivity over class II Histone Deacetylase (HDACs) and as well as class I HDACs. N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester was deteremined to be a potent and selective inhibitor of HDAC with reduced off-tar get activity and tumor growth inhibition activity.

?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,?????? ?? ?? ? ???

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?????,N-[[4-[[(4-a??[1,1'-???]-3-?)a??]????]??]??]-,?????? ?? ??

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