MI-773
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MI-773 ??? ???
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- ?? ??:
- 1303607-07-9
- ???:
- MI-773
- ???(??):
- MI-773;MI-773 (2'R,3S-isomer);(2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neop;(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide;(2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;Spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide, 6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2′R,3S,4′S,5′R)-
- CBNumber:
- CB12685929
- ???:
- C29H34Cl2FN3O3
- ??? ??:
- 562.5
- MOL ??:
- 1303607-07-9.mol
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MI-773 ??
- ?? ?
- 732.1±60.0 °C(Predicted)
- ??
- 1.36±0.1 g/cm3(Predicted)
- ?? ??
- Store at -20°C
- ???
- DMSO? ???
- ??? ??
- Solid
- ?? ?? (pKa)
- 12.03±0.70(Predicted)
- ??
- White to off-white
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????(GHS): |
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| ?? ?: |
Warning |
| ??·?? ??: |
| ?? |
??·?? ?? |
?? ?? |
?? |
?? ? |
?? ?? |
P- ?? |
| H302 |
??? ??? |
?? ?? ?? - ?? |
?? 4 |
?? |
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P264, P270, P301+P312, P330, P501 |
| H315 |
??? ??? ??? |
????? ?? ????? |
?? 2 |
?? |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H320 |
?? ??? ??? |
?? ? ?? ?? ??? ?? |
?? 2B |
?? |
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P264, P305+P351+P338,P337+P313 |
| H335 |
?? ???? ??? ? ?? |
?? ???? ?? - 1? ??;???? ?? |
?? 3 |
?? |
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| ??????: |
| P261 |
??·?·??·???·??·...·????? ??? ????. |
| P280 |
????/???/???/?????? ?????. |
| P301+P312 |
??? ???? ??? ????(??)? ??? ????. |
| P302+P352 |
??? ??? ??? ?? ????. |
| P305+P351+P338 |
?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????. |
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MI-773 C??? ??, ??, ??
??
MI-773 is an inhibitor of MDM2-p53 protein-protein interaction (MDM2 inhibitors), currently investigated in clinical trials for cancer treatment.
MI-773 ?? ?? ? ???
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?? ??
MI-773 ?? ??
???( 57)?? ??
