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Axitinib Impurity D

Axitinib Impurity D ??? ???

?? ??:: 1443118-72-6

???:: Axitinib Impurity D

???(??):: AxitinibG;Axitinib Impurity D;Acitinib impurity 10;N-methyl-2-[3-[(E)-2-pyridin-2-ylethenyl]-1-(2-pyridin-2-ylethyl)indazol-6-yl]sulfanylbenzamide;N-methyl-2-[[3-[(1E)-2-(2-pyridyl)vinyl]-1-[2-(2-pyridine)ethyl]-1H-indazole-6-yl]thiobenzamide;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1-[2-(2-pyridinyl)ethyl]-1H-indazol-6-yl]thio]-;Axitinib Impurity 8/(E)-N-methyl-2-(1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide;(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide (Axitinib Impurity)

CBNumber:: CB13038986

???:: C29H25N5OS

??? ??:: 491.61

MOL ??:: 1443118-72-6.mol

?? ?? 37

Axitinib Impurity D ??

?? ?: 734.9±60.0 °C(Predicted)

??: 1.23±0.1 g/cm3(Predicted)

?? ??: 2-8°C, stored under nitrogen

?? ?? (pKa): 14.44±0.46(Predicted)

??: Light yellow to green yellow Solid

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Axitinib Impurity D C??? ??, ??, ??

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(E)-N-methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide is an metabolite of Axitinib(A794650) which is is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

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Axitinib Impurity D ?? ??

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Axitinib Impurity D ?? ??:

BenzaMide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-Methyl- Axitinib Impurity 23 Axitinib Impurity 3 Axitinib Impurity a Axitinib Impurity 26 Axitinib Impurity 10 Axitinib Impurity 4 Axitinib Impurity 20 Axitinib Impurity 18 Axitinib Impurity 13 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide Axitinib Impurity 11 Axitinib Impurity 32 Axitinib Impurity 19 Axitinib Impurity 14 Axitinib Impurity 3 Axitinib Impurity b Axitinib Impurity 24

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