一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Barnidipine hydrochloride

Barnidipine hydrochloride ??? ???
?? ??:
104757-53-1
???:
Barnidipine hydrochloride
???(??):
ym730;Hypoca;ly198561;ym09730-5;Mepirodipine;BARNIDIPINE HCL;YM-09730-5:Hypoca;BARNIDIPINE HYDROCHLORIDE;mepirodipinehydrochloride;Barnidipine Hydrochloride l
CBNumber:
CB1397277
???:
C27H30ClN3O6
??? ??:
528
MOL ??:
104757-53-1.mol

Barnidipine hydrochloride ??

???
223-226°C
??
D20 +116.4° (c = 1 in methanol)
?? ??
Sealed in dry,Room Temperature
???
insoluble in H2O; insoluble in EtOH; ≥16.3 mg/mL in DMSO with gentle warming
??? ??
??? ??
??
Light yellow to yellow
CAS ??????
104757-53-1(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
?? LD50 orally in male, female rats: 105, 113 mg/kg (Satoh)
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
??????:
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

Barnidipine hydrochloride C??? ??, ??, ??

??

Barnidipine hydrochloride, chemically known as (3S)-1-benzyl-3-pyrrolidinylmethyl-(4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride, is a new long-acting dihydropyridine calcium antagonist developed and marketed by Yamanouchi Pharmaceutical (now Astellas Pharma). This medication effectively lowers blood pressure without impacting heart rate by specifically targeting calcium channels responsible for transmembrane potential. By inhibiting calcium influx into cells, it selectively relaxes smooth muscle in peripheral and coronary blood vessels.

??? ??

Pale Yellow Solid. Melting point 226-228°C. [α]D20+116.4° (C=1, methanol). Insoluble in water. Acute toxicity LD50 male and female rats (mg/kg): 105, 113 Oral.

??

Barnidipine hydrochloride is a vasodilating dihydropyridine calcium antagonist useful in the treatment of primary hypertension and renal hypertension. In experimental animals, its hypotensive effect was more potent and longer acting than nicardipine, nifedipine and nitrendipine.

??

ChEBI: Barnidipine hydrochloride is a dihydropyridine. 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. It is a potential candidate in the treatment of patients with renal parenchymal hypertension.

???? ??

Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery. It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day. Formulations containing barnidipine have been used as a treatment for hypertension.

?? ??

[1] WEGENERJ W. Barnidipine block of L-type Ca(2+) channel currents in rat ventricular cardiomyocytes.[J]. British Journal of Pharmacology, 2000. DOI:10.1038/sj.bjp.0703514.
[2] ALP YILDIRIMF ILKAY. Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats.[J]. European journal of pharmacology, 2015. DOI:10.1016/j.ejphar.2015.07.033.
[3] CHENGZHI-GANG. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.[J]. Molecules, 2014. DOI:10.3390/molecules19011344.

Barnidipine hydrochloride ?? ?? ? ???

???

?? ??


Barnidipine hydrochloride ?? ??

???( 138)?? ??
??? ?? ??? ?? ?? ? ??
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Win-Win chemical CO., Limited
+86-0086-577-64498589 +86-15355981851
sales@win-winchemical.com China 14304 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9996 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15083 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58

Barnidipine hydrochloride ?? ??:

Copyright 2019 ? ChemicalBook. All rights reserved
安溪县| 桦川县| 信阳市| 呼和浩特市| 阿拉善左旗| 东兴市| 怀远县| 芮城县| 东山县| 延津县| 金华市| 民权县| 柞水县| 罗山县| 达日县| 北流市| 洛南县| 博爱县| 油尖旺区| 永安市| 历史| 吴川市| 磐石市| 禄丰县| 深州市| 维西| 德安县| 宁强县| 盐山县| 抚宁县| 开远市| 蕉岭县| 铜川市| 高平市| 崇州市| 曲阜市| 田林县| 紫金县| 汕头市| 湖北省| 雷州市|