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GLP-1 (7-37)

GLP-1 (7-37) ??? ???
?? ??:
106612-94-6
???:
GLP-1 (7-37)
???(??):
HuMan GLP-1;insulinotropin;7-37-Glucagon-likepeptide;HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY;Tglp-1;GLP-1, 7-37;Glp-I (7-37);GLP-1(7-37), >98%;Human GLP-1 (7-37);GLP-1 acetate salt
CBNumber:
CB1445727
???:
C151H228N40O47
??? ??:
3355.67
MOL ??:
106612-94-6.mol

GLP-1 (7-37) ??

??
1.48±0.1 g/cm3(Predicted)
?? ??
−20°C
???
Water:30.0(Max Conc. mg/mL);8.34(Max Conc. mM)
??? ??
????? ??
??
White to off-white
???
2mg/ml? ?? ???
???
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH
InChIKey
GCYXWQUSHADNBF-AAEALURTSA-N
CAS ??????
106612-94-6

??

????? 22-24/25
WGK ?? 3
???? ??? 11 - Combustible Solids

GLP-1 (7-37) C??? ??, ??, ??

??

GLP-1 (7-37) is an endogenous truncated form of GLP-1 that arises from proglucagon processing in intestinal endocrine L cells, GLP-1 (7-37) acts as a GLP-1 receptor agonist and is an insulinotropic hormone that augments glucose induced insulin secretion. GLP-1 (7-37) and derivatives GLP-1 (9-37) and GLP-1 (28-37) can reduce plaque inflammation and increase phenotypic characteristics of plaque stability in a murine model of atherosclerosis.

??

Glucagon-Like Peptide 1 Fragment 7-37 human has been used:
  • as a positive control for insulin secretion of pancreatic islets
  • to test its effect on insulin response in horse islets
  • in combination with mesenchymal stem cells (MSCs) test its protective effects in myocardial infarction

?? ??

Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) is an amino-truncated form of GLP-1.

Biochem/physiol Actions

Glucagon-Like Peptide 1 Fragment 7-37 human (GLP-1-(7-37)) interacts with the GLP-1 receptor (GLP-1r). It mediates insulin release by stimulating the cyclic AMP accumulation in islet cells GLP-l(7-37) is a potential therapeutic agent due to its insulin-secretagogue functionality.

GLP-1 (7-37) ?? ?? ? ???

???

?? ??


GLP-1 (7-37) ?? ??

???( 223)?? ??
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