1-Adamantanemethanol
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1-Adamantanemethanol ??
- ???
- 114-117 °C (lit.)
- ?? ?
- 234.5°C (rough estimate)
- ??
- 0.8802 (rough estimate)
- ???
- 1.5000 (estimate)
- ?? ??
- Sealed in dry,Room Temperature
- ?? ?? (pKa)
- 15.51±0.10(Predicted)
- ??? ??
- ??? ??
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- ?? ???. ???? ?? ???(?? ???).
- BRN
- 1853339
- InChI
- InChI=1S/C11H18O/c12-7-11-4-8-1-9(5-11)3-10(2-8)6-11/h8-10,12H,1-7H2
- InChIKey
- MDVGOOIANLZFCP-UHFFFAOYSA-N
- SMILES
- C12(CO)CC3CC(CC(C3)C1)C2
- CAS ??????
- 770-71-8(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 22-24/25-36-26 | ||
| WGK ?? | 3 | ||
| ?? ?? | IRRITANT | ||
| HS ?? | 29061900 | ||
| ???? ??? | 11 - Combustible Solids |
1-Adamantanemethanol C??? ??, ??, ??
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1-Adamantanemethanol acts as guest molecule and forms β-cyclodextrin complexes. It reacts with 3,4,5,6-tetrafluorophthalonitrile to yield 3,4,5,6-tetra-(1-adamantylmethoxy)phthalonitrile.??? ??
white crystalline powder??
1-Adamantanemethanol was used in the synthesis of axially disubstituted silicon(IV) phthalocyanines. It is used as a reagent in the synthesis of adamantane and noradamantane based histone deacetylase (HDAC) inhibitors for the treatment of cancer. It is also used as a reagent in the synthesis of (1-adamantyl)methyl glycidyl ether, a versatile building block for living polymerization.References
Gopalan, B., et al.: Bioorg. Med. Chem. Lett., 23, 2532 (2013);
Suzuki, T., et al.: J. Med. Chem., 55, 9562 (2012);
Moers, C., et al.: Macromol. Rapid Comm., 35, 1075 (2014)
Purification Methods
Dissolve the adamantane in Et2O, wash it with aqueous 0.1N NaOH and H2O, dry over CaCl2, evaporate and recrystallise the residue from aqueous MeOH. [Stetter et al. Chem Ber 92 1629 1959, Beilstein 6 IV 400.]1-Adamantanemethanol ?? ?? ? ???
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1-Adamantanemethanol ?? ??
???( 416)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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1-Adamantanemethanol ?? ??:
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Altrenogest
Amantadine
methylol cellulose
FMOC-LYS(ADPOC)-OH
FMOC-DAB(ADPOC)-OH
2-Adamantone-5-carboxylic acid
Ethyl adamantane-1-carboxylate
AMANTANIUM BROMIDE
2-(1-Adamantyl)propan-2-ol
3,5-DIMETHYL-1-ADAMANTANEMETHANOL, 98%(GC)