4,4'-?????(2-??????)
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4,4'-?????(2-??????) ??
- ???
- 102-107 °C(lit.)
- ?? ?
- 202-214 °C0.3 mm Hg(lit.)
- ??
- 1.44
- ???
- 0.001Pa at 20℃
- ???
- 1.6710 (estimate)
- ???
- >230 °F
- ???
- ??????(?? ???), DMSO(?? ???), ???(?? ???)
- ??? ??
- solid
- ?? ?? (pKa)
- 3.33±0.25(Predicted)
- ??
- Light orange to Yellow to Green
- ???
- 25 ºC?? <0.1g/100mL
- Merck
- 14,6059
- BRN
- 1882318
- Henry's Law Constant
- 9.0×105 mol/(m3Pa) at 25℃, HSDB (2015)
- ???
- ?????? 200C ????? ?? ???? ??? ?? ????. ??? ???? ???? ????.
- ?? ??
- ??
- InChI
- 1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2
- InChIKey
- IBOFVQJTBBUKMU-UHFFFAOYSA-N
- SMILES
- Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
- LogP
- 2.5 at 25℃
- CAS ??????
- 101-14-4(CAS DataBase Reference)
- IARC
- 1 (Vol. Sup 7, 57, 99, 100F) 2012
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T,N | ||
|---|---|---|---|
| ?? ???? ?? | 45-22-50/53-53-50-68 | ||
| ????? | 53-45-60-61-36/37 | ||
| ????(UN No.) | UN 3077 9/PG 3 | ||
| OEB | E | ||
| OEL | TWA: 0.003 mg/m3 [skin] | ||
| WGK ?? | 3 | ||
| RTECS ?? | CY1050000 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 6.1(b) | ||
| ???? | III | ||
| HS ?? | 29215900 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Carc. 1B Muta. 2 |
||
| ?? ?? ??? | 101-14-4(Hazardous Substances Data) | ||
| ?? | LD50 oral in rat: 1140mg/kg | ||
| ???? ?? | KE-10102 | ||
| ?????? ??? | 98-1-479;06-5-13 | ||
| ?????? ??? | ??1-50 | ||
| ?? ? ???? | ????: ????; ???(??)????: 4,4'-?????(2-??????) ? ?? 0.1% ?? ??? ??? |
4,4'-?????(2-??????) C??? ??, ??, ??
??? ??
off-white powder??
MOCA (4,4'-Methylene bis(2-chloroaniline)) is widely used in machinery, automobile, aircraft manufacturing, mining, industrial and sports facilities (such as plastic track and plastic floor) can be used for curing and waterproof coatings such as epoxy resin, which can be given to polyester and polyether elastomer most good physical and mechanical properties and the results.?? ??
The production of MOCA (4,4'-Methylene bis(2-chloroaniline)) in the United States has ceased since 1979 and is now imported, mainly from Japan. More than 1.9 million lb was imported in 1989. The compound is currently used as a curing agent for isocyanate-containing polymers and in the manufacture of polyurethane foams, epoxy resins, gun mounts, jet engine turbine blades, radar systems, and components in home appliances. It is also a model compound for studying carcinogenesis.??
ChEBI: A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge.?? ??
Tan-colored pellets or an off-white solid. Slight odor.??? ?? ??
Insoluble in water.?? ???
4,4'-Methylene bis(2-chloroaniline) is a weak base. Undergoes an exothermic and self-sustaining decomposition reaction when exposed to heat above 392°F, In a closed container, the pressure buildup can be rapid enough to cause an explosion.???
Toxic. A confirmed carcinogen, absorbedby skin. Causes bladder cancer and methe-moglobinemia.????
4,4￠-Methylene bis(2-chloroaniline), or MOCA, is carcinogenic in experimental animals.????
Flash point data for 4,4'-Methylene bis(2-chloroaniline) are not available. 4,4'-Methylene bis(2-chloroaniline) is probably combustible.Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Mutation data reported. Flammable liquid. Reactive with active metals such as sodium, potassium, magnesium, or zinc. When heated to decomposition it emits very toxic fumes of Cland NOx.Carcinogenicity
4,4′-Methylenebis(2-chloroaniline) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.4,4'-?????(2-??????) ?? ?? ? ???
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?? ??
4,4'-?????(2-??????) ?? ??
???( 273)?? ??
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