?????
|
|
????? ??
- ???
- 280-282 °C(lit.)
- ??
- D25 +58° ±5° (0.04 g in 1 ml dioxane)
- ?? ?
- 370.61°C (rough estimate)
- ??
- 1.27
- ???
- 58 ° (C=0.4, Dioxane)
- ???
- 9℃
- ?? ??
- 2-8°C
- ???
- ??? ?? ?? ???, ????? ?? ?? ????(96%).
- ??? ??
- Solid
- ?? ?? (pKa)
- pKa 10.38±0.02(H2O t=23±2 Iunspecied) (Uncertain)
- ??
- ???? ?????
- ?? ??
- +6127 (95% ethanol)
- ???
- 3.2mg/L(25℃)
- Merck
- 3707
- BRN
- 2508172
- Henry's Law Constant
- 7.6×106 mol/(m3Pa) at 25℃, HSDB (2015)
- InChI
- 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
- InChIKey
- PROQIPRRNZUXQM-ZXXIGWHRSA-N
- SMILES
- C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O
- CAS ??????
- 50-27-1(CAS DataBase Reference)
- NIST
- Estriol(50-27-1)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T,F | ||
|---|---|---|---|
| ?? ???? ?? | 60-61-40-45-39/23/24/25-23/24/25-11 | ||
| ????? | 53-22-36/37/39-45-36/37-16 | ||
| ????(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
| WGK ?? | 3 | ||
| RTECS ?? | KG8225000 | ||
| F ?????? | 8-10 | ||
| HS ?? | 29072990 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Carc. 2 Lact. Repr. 1A |
||
| ?? ?? ??? | 50-27-1(Hazardous Substances Data) | ||
| ?? | LD50 oral in rat: > 2gm/kg |
????? C??? ??, ??, ??
??
Estriol is significantly less active than estradiol; however, it has a selective ability to stimulate blood flow and restoration of genital epithelium. In addition, using this drug reduces mental symptoms of menopausal syndrome. It is used in the premenopausal and menopausal periods, for skin atrophy and signs of genital degeneration, and so on.??? ??
White or almost white, crystalline powder.??
A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol??
ChEBI: A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer).?? ??
Estriol, estra-1,3,5(10)-triene-3,16 ,17 -triol, is available for compounding into several differentformulations for use in HRT. It can be used alone or in combinationswith estradiol (Bi-Est) or with estradiol and estrone(Tri-Est).???
A carcinogen (OSHA).Safety Profile
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Other experimental reproductive effects. Mutation data reported. A steroid drug for the treatment of menopause. When heated to decomposition it emits acrid smoke and irritating fumes.Purification Methods
Crystallise estriol from EtOH/ethyl acetate. Also purify it by countercurrent distribution with cyclohexane/EtOAc (1:1) and EtOH/H2O (1:1). The UV (EtOH) has max at 280nm ( 2,090 M-1cm-1). [Huffmann & Lott 71 719 1949, Leeds et al. J Am Chem Soc 76 2943 1954, Beilstein 6 IV 7550.]????? ?? ?? ? ???
???
????
2,4-Dibromo-β-D-Glucopyranosiduronic Acid Estrane Derivative
3,16alpha-dihydroxyestra-1,3,5(10)-trien-17-one 3,16-diacetate
16α,17α-Epoxy-1,3,5(10)-estratriene-3,17β-diol diacetate
1,3,5[10]-???????-3,16ALPHA-DIOL-17-ONE
16-??????
2,4,16a-?????????
2,4-????-16a-????????
????-1,3,5(10),16-????-3,17-????????
17-BETA-ESTRADIOL 3-METHYL ETHER
?? ??
????? ?? ??
???( 640)?? ??
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????? ?? ??:
?????
Motolimod
β-Estradiol
ESTRIOL TRISULFATE TRISODIUM SALT,ESTRIOL TRISULPHATE, TRISODIUM SALT
ESTETROL
ESTRIOL 16,17-DIACETATE
quinestradol
ESTRIOL 3-BENZYL ETHER
ESTRIOL IMPURITY A
ESTRIOL 16-GLUCURONIDE,ESTRIOL 16ALPHA-(BETA-D-GLUCURONIDE)
9,11-Didehydroestriol
ESTRIOL IMP. B (EP): 3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE (ESTRONE)
EPIMESTROL
Quinestrol
Nilestriol
16beta,17beta-Estriol,3,16beta,17beta-Estriol
estriol succinate
6-KETOESTRIOL