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(+/-)-?????-4-????? ???

(+/-)-?????-4-????? ???
(+/-)-?????-4-????? ??? ??? ???
?? ??:
19438-60-9
???:
(+/-)-?????-4-????? ???
???(??):
(+/-)-?????-4-????????;(+/-)-?????-4-????????((+/-)-HEXAHYDRO-4-METHYLPHTHALICANH...
???:
Hexahydro-4-methylphthalic anhydride
???(??):
MHHPA;4-MHHPA;5-Methylhexahydroisobenzofuran-1,3-dione;Rikacid MH;Hexahydro-4-methyL;HEXAHYDRO-4-METHYLPHTH;Methylaexahydrophthalic Anhydride;methyl hexahydrophtalic anhydride;5-Methylhexahydrophthalicanhydride;4-Methylhexahydrohthalic anhydride
CBNumber:
CB2125569
???:
C9H12O3
??? ??:
168.19
MOL ??:
19438-60-9.mol

(+/-)-?????-4-????? ??? ??

???
-29°C
?? ?
120°C (1 mmHg)
??
1.162 g/mL at 25 °C(lit.)
???
0.23Pa at 25℃
???
n20/D 1.477(lit.)
???
>230 °F
?? ??
Inert atmosphere,Room Temperature
???
?????(?? ???), ???????(?? ???)
?? ?? (pKa)
4.24[at 20 ℃]
??? ??
??
??
???
???
?? ??
??
Moisture Sensitive
???
???, ?? ???
InChI
1S/C9H12O3/c1-5-2-3-6-7(4-5)9(11)12-8(6)10/h5-7H,2-4H2,1H3
InChIKey
FKBMTBAXDISZGN-UHFFFAOYSA-N
SMILES
CC1CCC2C(C1)C(=O)OC2=O
LogP
-3.95 at 20℃
CAS ??????
19438-60-9(CAS DataBase Reference)
EPA
1,3-Isobenzofurandione, hexahydro-5-methyl- (19438-60-9)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 41-42/43
????? 22-24-26-37/39
WGK ?? 1
?? ?? ?? Irritant
TSCA TSCA listed
HS ?? 29172090
???? ??? 10 - Combustible liquids
Hazard Classifications Eye Dam. 1
Resp. Sens. 1
Skin Sens. 1
???? ?? KE-18587
?????? ??? ??1-178
????(GHS): Corrosion (GHS05)Health Hazard (GHS08)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? P280, P305+P351+P338, P310
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? P261, P285, P304+P341, P342+P311,P501
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P272 ??? ??? ??? ??? ???? ???.
P280 ????/???/???/?????? ?????.
P284 ?? ???? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
1
2 0

(+/-)-?????-4-????? ??? MSDS


MHHPA

(+/-)-?????-4-????? ??? C??? ??, ??, ??

??

Methylhexahydrophthalic anhydride (MHHP A) is an epoxy hardener, irritant to skin and mucus membranes. It is included in non-diglycidyl-ether-of-bisphenol- A epoxy resins. It can induce both allergic contact dermatitis and immunologic contact urticaria. MHHP A is structurally close to methyltetrahydrophthalic anhydride (MTHP A), which can also cause sensitization.

??? ??

Hexahydro-4-methylphthalic anhydride has a melting point of 29 °C, so it is a liquid at room temperature. It has a boiling point of 120 °C and at 25 °C its density is 1.162 g/mL.

??

Hexahydro-4-methylphthalic anhydride, mixture ofcisandtrans may be used as an analytical standard for the determination of the analyte in human biological samples by gas chromatography-mass spectrometry (GC-MS).

?? ??

Methylhexahydrophthalic anhydride, a congener of phthalic anhydride, is utilized in the production of plastics, paints, and electronic components. It can potentially result in allergenic effects on humans upon exposure and cause immunological reactions.

?? ?? ??

Methylhexahydrophthalic anhydride is an epoxy hardener, irritant to skin and mucous membranes. It is included in nondiglycidyl-ether-of-bisphenol-A epoxy resins. It can induce both allergic contact dermatitis and immunologic contact urticaria. It is structurally close to methyltetrahydrophthalic anhydride, which can also cause sensitization.

Synthesis

5-methyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione could used as a starting material to synthesize Hexahydro-4-methylphthalic anhydride. The byproducts include 5-methylisobenzofuran-1,3-dione, 5-methyl-4,5,6,7-tetrahydroisobenzofuran-1,3-dione, and 6-methyl-3a,4,5,7a-tetrahydroisobenzofuran-1,3-dione.
Hexahydro-4-methylphthalic anhydride

(+/-)-?????-4-????? ??? ?? ?? ? ???

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