????????????
|
|
???????????? ??
- ???
- 208-210 °C
- ???
- -14 ° (C=1, H2O)
- ?? ??
- 2-8°C
- ???
- ?(?? ???)
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 6.4, 9.5(at 25℃)
- ??
- ???
- ???? ??
- (chemical)
- ???
- 40g/100mL(20℃)
- BRN
- 3582885
- ???
- ???? ?? ??
- ??? ?? ??
- ?? ????
- InChI
- InChI=1/C9H13N2O9P.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
- InChIKey
- KURVIXMFFSNONZ-WFIJOQBCSA-L
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,11,r|
- CAS ??????
- 3387-36-8(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 22-24/25-36-26 | ||
| WGK ?? | 2 | ||
| RTECS ?? | YU7975000 | ||
| F ?????? | 10-21 | ||
| HS ?? | 29389090 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ???? ?? | KE-12408 |
???????????? C??? ??, ??, ??
????
? (1) ?? : ? ?? 0.5g? ? 10mL? ?? ?, ? ?? ????? ??? ?? ?? ????? ??.
??(2) ?? : ? ??? ???(1→20)? pH? 7.0～8.5??? ??.
??(3) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.
??(4) ? : 「???????」? ???? (2)? ?? ????(2.0ppm ??).
??(5) ??? : ? ??? 0.01N ??(1→50,000)? ?? 250nm, 260nm ? 280nm??? ??? A1, A2 ? A3? ??? ? A1/A2? 0.70～0.78, A3/A2? 0.34～0.42??? ??.
??(6) ?? ????? : ? ??? ???(0.1→10) 1μL? ?????? ?? ????????????????????(1→10)? ??(2 : 2 : 1)? ?????? ?? ?????????? ?? ?, ??? ??? ???. ??, ???? ???? ?????????? ???????? 60～80℃?? 20?? ???? ?? ????. ?????? ??? ?????? 10cm ???? ? ??? ??? ??? ?? ?? ???? ???(?? ? 250nm)??? ????. ??, ???? ???? ????.
????
? (1) ? ?? 20mg? 0.01N ?? 100mL? ??? ? ? 10mL? 0.01N ??? ??? 100mL? ? ?? ?? 262±2nm? ?????? ??.
??(2) ? ??? ???(3→10,000) 3mL? ?? 1mL ? ???? 1mL? ??? ?? ??? 30?? ???? ??? ?? ?? ??? ??? ? ???????(1→10) 0.2mL? ??? ????????????(1→1,000) 3mL? ??? ?? ??? 20?? ???? ??? ????.
??(3) ? ??? ???(1→20) 5mL? ??????? 2mL? ?? ?, ??? ??? ????. ?? ?? 7mL? ??? 10?? ?? ?? ????????(1→25)? ??? ??? ?? ????? ? ??? (?)? ??? ????.
??(4) ? ??? ????? ? ????? ??? ????.
???
? ? ?? ? 500mg? ??? ?? 0.01N ??? ?? 1,000mL? ?? ? ? 10mL? 0.01N ??? ??? 250mL? ?? ?????? ??. 0.01N ??? ????? ?? ??? ?? 1cm? ?? 260nm? ???? ??? A? ???? ?? ???? ?? 5''-????????? ??? ???.
??? ??
The protonation of disodium Uridine 5′-monophosphate disodium salt and cytidine 5' -monophosphate (a homolog of UMP) not only depend on the electrostatic forces but also strongly depend on the solute–solvent interactions of the different species in the mixtures. In the case of UMP, the correlation analysis of log10 K2 and log10 K1 (including β and π*) shows the polarity parameter has a major role (about 58 and 56 %, respectively) and the negative sign of π* and positive sign of β indicate that a decrease in the polarity of the media increases the protonation constants[1].??
Uridine 5'-monophosphate disodium salt （UMP-Na2） is a major component of RNA, a nucleotide. It is found in dietary supplements as well as in natural foods rich in RNA and has been shown to enhance cognitive function in animals.?? ??
Uridine 5′-monophosphate disodium salt can be used as a cross-linking agent to prepare thermosensitive chitosan hydrogels containing graphene oxide as nanofillers. The hydrogels are attractive materials for use as scaffolds for the regeneration of damaged tissues[3].benefits
Membrane phospholipids like phosphatidylcholine (PC) are required for cellular growth and repair, specifically for synaptic function. PC synthesis is controlled by cellular levels of its precursor, cytidine-5'-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. In rat PC12 cells, exogenous uridine was shown to elevate intracellular CDP-choline levels by promoting the synthesis of uridine triphosphate (UTP), which was partly converted to CTP. In such cells, uridine also enhances the neurite outgrowth produced by the nerve growth factor (NGF). A study assessed the effect of dietary supplementation with uridine-5'-monophosphate disodium (UMP-2Na+, an additive in infant milk formulas) on striatal dopamine (DA) release in aged rats. Potassium (K+)-evoked DA release was significantly greater among UMP-treated rats, i.e., 341+/-21% of basal levels vs. 283+/-9% of basal levels in control rats (p<0.05); basal DA release was unchanged. The levels of neurofilament-70 and neurofilament-M proteins, biomarkers of neurite outgrowth, increased to 182+/-25% (p<0.05) and 221+/-34% (p<0.01) of control values, respectively, with UMP consumption. Hence, UMP treatment not only enhances membrane phosphatide production but also can modulate two membrane-dependent processes, neurotransmitter release and neurite outgrowth, in vivo[2].?? ??
Uridine 5′-monophosphate is a pyrimidine mononucleotide. It is formed by decarboxylation of orotidine 5′-monophosphate. UMP is further converted to UTP (uridine 5′-triphosphate) using kinases.???????????? ?? ?? ? ???
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?? ??
???????????? ?? ??
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???????????? ?? ??:
???? ?????????????, ???? ? ?? 5′-???????? 5-????-2'-?????? 5′-???????? ?? ??????????? ????????? ?????? ??? ???? ???? ??? URIDINE5'-???????????4-MORPHOLINE-N,N'-DICYCLOHEXYLCARBOXAMIDINESALT ????
DISODIUM GLYCYRRHIZATE
Doxifluridine
Disodium stannous citrate
uridine diphosphate glucose {= UDP-glucose}
Cromolyn Disodium Salt
1-beta-D-Arabinofuranosyluracil