ChemicalBook >?? ???? >?????????????
?????????????
|
|
????????????? ??
- ?? ?
- 152-154 °C(Press: 10 Torr)
- ??
- 1.047±0.06 g/cm3(Predicted)
- ???
- 0.062-0.115Pa at 20-25℃
- ?? ??
- Sealed in dry,Room Temperature
- ??? ??
- Liquid:viscous
- ?? ?? (pKa)
- 14.69±0.10(Predicted)
- ??? ?? ??
- ?? ???
?? ????
- InChI
- InChI=1S/C10H15NO/c1-9-3-5-10(6-4-9)11(2)7-8-12/h3-6,12H,7-8H2,1-2H3
- InChIKey
- HXCWOOAEAHVMBJ-UHFFFAOYSA-N
- SMILES
- C(O)CN(C)C1=CC=C(C)C=C1
- LogP
- 2.2 at 25℃ and pH6
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| TSCA | TSCA listed | ||
|---|---|---|---|
| HS ?? | 2933599590 |
| ????(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
| ??·?? ??: |
|
|||||||||||||||||||||||||||||||||||
| ??????: |
|
????????????? C??? ??, ??, ??
??
N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE is an amine organic compound, which can be used as intermediate in organic synthesis.Synthesis
Add reactant (0.2 mmol, 1.0 equiv), THF (2.0 mL) and CH2Br2 (0.6 mmol, 3.0 equiv) to a flame-dried 10 mL Schlenk tube in a glove box. Seal and take out of the glove box. Cool the reaction mixture to -78°C. Add nBuLi (0.56 mmol, 2.8 equiv) dropwise under N2 atmosphere within 3minutes. Stir the reaction at -78°C for 30 minutes and add ZnCl2 (0.1 mL, 0.5equiv, 1.0 M in Et2O). Allow the mixture to warm to room temperature and stir for 1 hour. Cool the mixture to 0°C. Add a premixture of H2O2 (30% in H2O, 0.5 mL) and NaOH (2.0 M, 1.0 mL). Stir the mixture at room temperature for another 1 hour and dilute with water (20 mL). Extract with DCM (30 mL x 2) and dry over Na2SO4. Filter and concentrate under vacuum. Purify the crude product by silica gel flash column chromatography to obtain product. 1H NMR (CDCl3, 500 MHz) δ 7.08 (d, J = 8.4 Hz, 2H), 6.78 (d, J = 8.4 Hz,2H), 3.80 (t, J = 5.6 Hz, 2H), 3.43 (t, J = 5.4 Hz, 2H), 2.93 (s, 3H), 2.28 (s, 3H), 2.01 (brs, 1H). 13C NMR (CDCl3, 125 MHz) δ 148.3, 129.8, 127.1, 114.0, 60.1, 56.2, 39.1, 20.4.
Fig The synthetic method of N-(2-hydroxyethyl)-N-methyl-4-toluidine
????????????? ?? ?? ? ???
???
?? ??
????????????? ?? ??
???( 162)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Yancheng Green Chemicals Co.,Ltd | +undefined-86-25-86655873 |
info@royal-chem.com | China | 130 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 |
info@finetechnology-ind.com | China | 9539 | 58 |
| Nexal Inc | +86-13962173137; |
info@nexalinc.com | Americas | 31 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 |
Sibel@chuanghaibio.com | China | 8737 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21531 | 55 |
| Anhui Royal Chemical Co., Ltd. | +86-025-86655873 +86-13962173137 |
marketing@royal-chem.com | China | 201 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2984 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 |
sales@amoychem.com | China | 6361 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19935 | 58 |
| Gansu Jinyuantai New Material Co., Ltd. | +86-025-86618065 +86-13914714331 |
marketing@royal-chem.com | China | 95 | 58 |
????????????? ?? ??:
????? N,4-???????? 2,2'-(??-?????)???? 1,1""-(p-?????)????-2-? ?????-5-???
4-Nitro-N-methylphthalimide
N-Methylaniline
N-(2-Hydroxyethyl)-N-methylaniline
Fura 2-AM
4-MORPHOLINOACETOPHENONE
3-AMINO-4-(4-MORPHOLINO)BENZOTRIFLUORIDE
2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n
FLAVIN ADENINE DINUCLEOTIDE
QUIN 2-AM
INDO 1-AM
INDO 1 PENTAPOTASSIUM SALT
1-(4-MORPHOLINO-3-NITROPHENYL)-1-ETHANONE
4-MORPHOLINOBENZOPHENONE