4,6-Dichloro-2-methylpyrimidine
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4,6-Dichloro-2-methylpyrimidine ??
- ???
- 41.5-45.5 °C (lit.)
- ?? ?
- 210.8±20.0 °C(Predicted)
- ??
- 1.404±0.06 g/cm3(Predicted)
- ???
- 208 °F
- ?? ??
- Keep in dark place,Sealed in dry,Room Temperature
- ???
- ???? ???
- ?? ?? (pKa)
- -3.84±0.30(Predicted)
- ??? ??
- ??? ?? ?? ??
- ??
- ???? ?????
- InChI
- InChI=1S/C5H4Cl2N2/c1-3-8-4(6)2-5(7)9-3/h2H,1H3
- InChIKey
- FIMUTBLUWQGTIJ-UHFFFAOYSA-N
- SMILES
- C1(C)=NC(Cl)=CC(Cl)=N1
- CAS ??????
- 1780-26-3(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | C,N,Xn | ||
|---|---|---|---|
| ?? ???? ?? | 34-51/53-43-22 | ||
| ????? | 26-36/37/39-45-61-36/37 | ||
| ????(UN No.) | UN 3261 8/PG 2 | ||
| WGK ?? | 3 | ||
| ?? ?? | 8 | ||
| ???? | III | ||
| HS ?? | 29335990 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 Skin Sens. 1 |
4,6-Dichloro-2-methylpyrimidine C??? ??, ??, ??
??? ??
White to off-white solid?? ??
The primary application of 4,6-dichloro-2-methylpyrimidine is as a key intermediate in the synthesis of the antihypertensive drug Moxonidine. Moxonidine is a centrally acting antihypertensive drug that exerts its antihypertensive effect by activating central α? receptors and imidazoline receptors. In its synthetic route, 4,6-dichloro-2-methylpyrimidine is used to construct the pyrimidine ring core structure, and key groups are introduced through substitution and other reactions to ultimately synthesize the target drug.4,6-Dichloro-2-methylpyrimidine ?? ?? ? ???
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Moxonidine
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4-CHLORO-2,6-DIMETHYLPYRIMIDINE
4-Pyrimidinamine, 2-methyl- (9CI)
4-Amino-6-chloro-2-methylpyrimidine
Pyrimidine, 4-amino-2-methyl-6-(methylamino)- (6CI,8CI)
4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine
6-???-N,N,2-????-4-??????
4-(6-CHLORO-2-METHYLPYRIMIDIN-4-YL)MORPHOLINE
6-???-N-??-2-??????-4-??
2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine
????
4,6-Dichloro-2-methylpyrimidine ?? ??
???( 586)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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4,6-Dichloro-2-methylpyrimidine ?? ??:
???? ?? ?? ???????? ?????-?? 2-???-5-???????? 4,6-???????? ?????????? ????????? ????
4,6-Dihydroxypyrimidine
4-Ethyl-5-fluoro-6-hydroxypyrimidine
2-Methylpyrimidine
4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
4,6-Dichloro-2-(methylthio)pyrimidine
4,7-Dichloro-6-nitroquinazoline
Furo[2,3-d]pyridazine, 4,7-dichloro
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE
4,6-dichloro-2-propylthiopyrimidine-5-amine
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine