ChemicalBook >?? ???? >?? ???>??? ?? ?? ???>??? ???>??? ???>2-Amino-5-bromo-3-(hydroxymethyl)pyridine
2-Amino-5-bromo-3-(hydroxymethyl)pyridine
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2-Amino-5-bromo-3-(hydroxymethyl)pyridine ??
- ???
- 137-140°C
- ?? ?
- 343.5±37.0 °C(Predicted)
- ??
- 1.766±0.06 g/cm3(Predicted)
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- under inert gas (nitrogen or Argon) at 2–8 °C
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- ? ??????, ???????, ???
- ?? ?? (pKa)
- 13.16±0.10(Predicted)
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- InChI
- InChI=1S/C6H7BrN2O/c7-5-1-4(3-10)6(8)9-2-5/h1-2,10H,3H2,(H2,8,9)
- InChIKey
- HIVQAWXDBPYNDU-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C=C1CO
- CAS ??????
- 335031-01-1(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ?? | IRRITANT | ||
| HS ?? | 2933399990 |
2-Amino-5-bromo-3-(hydroxymethyl)pyridine C??? ??, ??, ??
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2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.Synthesis
2-Amino-5-bromo-3-(hydroxymethyl)pyridineBromine (8.4 mL, 189.4 mmol) was added dropwise over 1 hour to a solution of 2- amino-3-(hydroxymethyl)pyridine (19.6 g, 157.8 mmol) in acetic acid (350 mL) at room temperature. The reaction mixture was then stirred overnight. After concentration to dryness, the residue was partitioned between a saturated solution of potassium carbonate (300 mL) and ethyl acetate (200 ml_). The aqueous layer was separated and extracted with ethyl acetate (2 x 200 ml_). The combined organic phases were washed with a saturated solution of sodium chloride (200 ml_), dried over sodium sulfate, filtered and concentrated to dryness. After trituration of the residue in pentane, the title product was obtained as a yellow solid (27.0 g, 84%).2-Amino-5-bromo-3-(hydroxymethyl)pyridine ?? ?? ? ???
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2-Amino-5-bromo-3-(hydroxymethyl)pyridine ?? ??
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2-Amino-5-bromo-3-(hydroxymethyl)pyridine ?? ??:
2-Amino-5-bromopyridine
(5-BROMO-PYRIDIN-3-YL)-METHANOL
2-Amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide
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5-BROMO-6-METHYL-2-METHYLAMINO-NICOTINIC ACID
IFLAB-BB F2124-0031
ETHYL 2-AMINO-5-BROMONICOTINATE
2-AMINO-5-BROMO-4-METHYL NICOTINIC ACID HCL
methyl 5-bromo-2-morpholinonicotinate
5-bromo-2-piperidinonicotinic acid
Methyl 2-amino-5-bromonicotinate
methyl 5-bromo-2-piperidinonicotinate
IFLAB-BB F2124-0032
tert-Butyl 4-[5-bromo-3-(methoxycarbonyl)pyridin-2-yl]piperazine-1-carboxylate
2-Amino-5-bromo-3-(hydroxymethyl)pyridine