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Dacomitinib (PF299804)

Dacomitinib (PF299804) ??? ???

?? ??:: 1110813-31-4

???:: Dacomitinib (PF299804)

???(??):: Dacomitinib;PF299804;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide Dacomitinib (PF299804, PF299);(E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide;PF299;CS-168;Dachtini;Dakotinib;dacatinib;Dacotinib

CBNumber:: CB22566418

???:: C24H25ClFN5O2

??? ??:: 469.94

MOL ??:: 1110813-31-4.mol

MSDS ??:: SDS

?? ?? 401

Dacomitinib (PF299804) ??

???: 184-187°C

?? ?: 665.7±55.0 °C(Predicted)

??: 1.344

?? ??: Refrigerator

???: DMSO(?? ???), ???(?? ???, ??)

??? ??: ?? ??.

?? ?? (pKa): 12.05±0.43(Predicted)

??: ???? ?? ???

InChIKey: LVXJQMNHJWSHET-AATRIKPKSA-N

SMILES: C(NC1C(OC)=CC2C(C=1)=C(NC1=CC=C(F)C(Cl)=C1)N=CN=2)(=O)/C=C/CN1CCCCC1

CAS ??????: 1110813-31-4

?? ? ?? ??
?? ? ???? ?? (GHS)

WGK ??	WGK 3
HS ??	29335990
???? ???	11 - Combustible Solids

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??		P264, P270, P301+P312, P330, P501

??????:

P280	????/???/???/?????? ?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

Dacomitinib (PF299804) C??? ??, ??, ??

??

The epidermal growth factor receptors (EGFR), whose members include ErbB1 (HER1), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4), are receptor tyrosine kinases that are often over-expressed in cancer. PF-299804 is a second generation pan-ErbB receptor tyrosine kinase inhibitor (IC₅₀s = 6, 45.7, and 73.7 nM for ErbB1, ErbB2, and ErbB4, respectively) that irreversibly binds to the ATP site in the catalytic domains of ErbB receptors. At 15 mg/kg, it demonstrates antitumor activity ranging from delay in tumor growth to complete regression in various tumor xenograft models expressing either wild-type ErbB or mutant ErbB family members that show resistance to first generation ErbB kinase inhibitors.

??

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

??

ChEBI: A member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin 1-yl)but-2-enoyl group.

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Vizimpro^TM

Dacomitinib (PF299804) ?? ?? ? ???

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Dacomitinib (PF299804) ?? ??

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???	??	???	??	?? ?	??
Protheragen-ING	+86-15618352007	info@protheragen-ing.com	United States	3867	58
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177	faithe@yan-xi.com	China	5838	58
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	sales@sdperfect.com	China	293	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9935	58
Anhui Ruihan Technology Co., Ltd	+undefined17756083858	daisy@anhuiruihan.com	China	954	58
Shaanxi TNJONE Pharmaceutical Co., Ltd		sarah@tnjone.com	China	1139	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +86-13795318958	bj1@bj-chem.com	China	299	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	874	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60

Dacomitinib (PF299804) ?? ??:

????? Tofacitinib Dasatinib 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Olmutinib AZD 3759 AG 1478 HYDROCHLORIDE OSI-420 Anlotinib EGF816 Tucatinib Neratinib Poziotinib (HM781-36B) Gefitinib CO-1686 Ibrutinib Lorlatinib (PF-06463922) XL647

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