ChemicalBook >?? ???? >7,11-???-10-??????????

7,11-???-10-??????????

7,11-???-10-?????????? ??? ???

?? ??:: 947687-01-6

???:: 7,11-???-10-??????????

???(??):: 7,11-???-10-??????????

???:: 7,11-Diethyl-10-hydroxycaMptothecin

???(??):: Irinotecan EP Impurity G;(S)-4,8,11-triethyl-4,9-dihydroxy-;Irinotecan Impurity 17(Irinotecan EP Impurity G);IRINOTECAN EP IMPURITY G (7,11-DIETHYL-10-HYDROXY CAMPTOTHECIN);(S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione;(4S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,8,11-triethyl-4,9-dihydroxy-, (4S)-;(S)-4,8,11-triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (Irinotecan Impurity）;(S)-4,8,11-triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione? (Irinotecan Impurity）

CBNumber:: CB22695545

???:: C24H24N2O5

??? ??:: 420.46

MOL ??:: 947687-01-6.mol

?? ?? 64

7,11-???-10-?????????? ??

?? ?: 798.1±60.0 °C(Predicted)

??: 1.44±0.1 g/cm3(Predicted)

?? ??: 2-8°C, sealed storage, away from moisture and light

???: DMSO(?? ???)

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 9.43±0.40(Predicted)

??: ?? ????? ?????

InChI: InChI=1S/C24H24N2O5/c1-4-12-7-18-14(8-20(12)27)13(5-2)15-10-26-19(21(15)25-18)9-17-16(22(26)28)11-31-23(29)24(17,30)6-3/h7-9,27,30H,4-6,10-11H2,1-3H3/t24-/m0/s1

InChIKey: BQAJEBSARMNUPK-DEOSSOPVSA-N

SMILES: N1C2C(=CC(O)=C(CC)C=2)C(CC)=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P280	????/???/???/?????? ?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

7,11-???-10-?????????? C??? ??, ??, ??

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7,11-Diethyl-10-hydroxycamptothecin is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500).

7,11-???-10-?????????? ?? ?? ? ???

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7,11-???-10-?????????? ?? ??

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7,11-???-10-?????????? ?? ??:

1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione 20R-Camptothecin (+)-Camptothecin Irinotecan sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate SN-38 GLUCURONIDE 11-Desethyl Irinotecan Irinotecan Impurity 26 (R)-SN-38 12-ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate GURKHSYORGJETM-MGDILKBHSA-N RPR 121056 Irinotecan Impurity 5 Irinotecan IMpurity G Irinotecan EP Impurity K (Mixture of Diastereomers) 7-Ethyl-10-hydroxycamptothecin 7-Ethylcamptothecin

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