???????,2-[????(4-?????)???]-
???????,2-[????(4-?????)???]- ??
?? ?
415.3±45.0 °C(Predicted)
??
1.279±0.06 g/cm3(Predicted)
?? ??
Storage temp. 2-8°C
?? ?? (pKa)
4.65±0.50(Predicted)
??
Light yellow to green yellow Solid
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H302
??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H315
??? ??? ???
????? ?? ?????
?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319
?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
??
P264, P280, P305+P351+P338,P337+P313P
H335
?? ???? ??? ? ??
?? ???? ?? - 1? ??;???? ??
?? 3
??
??????:
P261
??·?·??·???·??·...·????? ??? ????.
P264
?? ??? ?? ??? ????.
P264
?? ??? ?? ??? ????.
P270
? ??? ??? ??? ???, ???? ???? ???.
P271
?? ?? ??? ? ?? ???? ?????.
P280
????/???/???/?????? ?????.
P302+P352
??? ??? ??? ?? ????.
P304+P340
???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338
?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P330
?? ?????.
P403+P233
??? ??? ? ?? ?? ??? ???? ?????.
P405
???? ?????.
P501
...? ??? / ??? ?? ???.
???????,2-[????(4-?????)???]- C??? ??, ??, ??
???????,2-[????(4-?????)???]- ?? ?? ? ???
???
?? ??
???????,2-[????(4-?????)???]- ?? ??
???( 84)?? ??
China 82
India 1
United States 1
Global 84
???????,2-[????(4-?????)???]- ?? ??:
Zanubrutinib
Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-
4-PHENOXYBENZOIC ACID
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
(R)-Zanubrutinib
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)-
tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-
1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim
Ibrutinib
Ibrutinib Dimer Impurity
(R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethanone
Ibrutinib Impurity 28
2-Propen-1-one, 1-[(3R)-3-[4-amino-7-oxido-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-
Ibrutinib Impurity 20
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine