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TRIMETHYLCOLCHICINIC ACID

TRIMETHYLCOLCHICINIC ACID ??? ???
?? ??:
3482-37-9
???:
TRIMETHYLCOLCHICINIC ACID
???(??):
NSC 36796;Aids002892;Aids-002892;Deacetylcolchiceine;Desacetylcolchiceine;deacetylcholchiceine;n-deacetyl-colchicein;desacetylcholchiceine;N-DEACETYLCOLCHICEINE;trimethyl-colchicinicaci
CBNumber:
CB2398165
???:
C19H21NO5
??? ??:
343.37
MOL ??:
3482-37-9.mol

TRIMETHYLCOLCHICINIC ACID ??

???
>230°C (dec.)
?? ?
478.65°C (rough estimate)
??
1.2726 (rough estimate)
???
1.5000 (estimate)
?? ??
−20°C
???
?????(??, ??? ??), DMSO(??), ???(??), ??? ? ???
??? ??
??
??? ??
??? ??
??
?? ???? ?????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 20/21/22
????? 36
WGK ?? 3
RTECS ?? GH0960000
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
H312 ??? ???? ??? ?? ?? ?? - ?? ?? 4 ?? P280,P302+P352, P312, P322, P363,P501
H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? P261, P271, P304+P340, P312
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P312 ???? ??? ????(??)? ??? ????.
P322 ?? ??(??? … ??)
P330 ?? ?????.
P363 ?? ??? ??? ??? ?????.
P501 ...? ??? / ??? ?? ???.

TRIMETHYLCOLCHICINIC ACID C??? ??, ??, ??

??

A minor alkaloid of the colchicine class, this base was first isolated from the seeds and corms of Colchicum autumnale, Gloriosa virescens and Littoria modesta and subsequently by Russian workers from Merendera robusta Bge. Several specific rotations have been measured, e.g. [α]D - 184°, - 152° and - 180° (all in CHC13). The base is separated from the numerous accompanying alkaloids by chromatography and countercurrent distribution.

??? ??

Yellow-green Solid

?? ??

Potesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)
Trudykulov, Yusupov, Sadykov, Khim. Prir. Soedin., 8,247 (1972)
Yusupov, Tr. Tashkent Fan., Uzbek SSR, 20, 24 (1972)

TRIMETHYLCOLCHICINIC ACID ?? ?? ? ???

???

?? ??


TRIMETHYLCOLCHICINIC ACID ?? ??

???( 34)?? ??
??? ?? ??? ?? ?? ? ??
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TRIMETHYLCOLCHICINIC ACID ?? ??:

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