????????
|
|
???????? ??
- ???
- 198-204°C
- ?? ?
- 371.31℃[at 101 325 Pa]
- ??
- 1.4235 (rough estimate)
- ???
- 0Pa at 25℃
- ???
- 1.6390 (estimate)
- ?? ??
- Keep in dark place,Sealed in dry,Room Temperature
- ???
- ??? ?? ?? ???, ?????????? ? ??, ???? ????? ?? ????(96%).
- ??? ??
- Solid
- ?? ?? (pKa)
- 3.40±0.36(Predicted)
- ??
- ???? ?? ???
- ???? ??
- rabbit
- ???
- 400mg/L at 28℃
- Merck
- 14,7377
- BRN
- 359901
- ?? ??
- ???(???)
- InChI
- 1S/C17H13N3O5S2/c21-15(13-3-1-2-4-14(13)16(22)23)19-11-5-7-12(8-6-11)27(24,25)20-17-18-9-10-26-17/h1-10H,(H,18,20)(H,19,21)(H,22,23)
- InChIKey
- PBMSWVPMRUJMPE-UHFFFAOYSA-N
- SMILES
- OC(=O)c1ccccc1C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccs3
- LogP
- -2 at 28℃
- CAS ??????
- 85-73-4(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????? | 24/25 | ||
|---|---|---|---|
| ????(UN No.) | 3249 | ||
| WGK ?? | WGK 3 | ||
| RTECS ?? | TH8575000 | ||
| TSCA | TSCA listed | ||
| ?? ?? | 6.1(b) | ||
| ???? | III | ||
| HS ?? | 29350090 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Aquatic Chronic 3 | ||
| ?? | LD50 i.p. in mice: 920 mg/kg (Mattis) |
???????? C??? ??, ??, ??
??? ??
White or yellowish-white, crystalline powder.??
Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.??
ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.?? ??
It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.
World Health Organization (WHO)
Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.???????? ?? ?? ? ???
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?? ??
???????? ?? ??
???( 290)?? ??
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