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3':5'-??-???????5'-????????????

3':5'-??-???????5'-????????????
3':5'-??-???????5'-???????????? ??? ???
?? ??:
9040-59-9
???:
3':5'-??-???????5'-????????????
???(??):
3':5'-??-???????5'-????????????
???:
3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE
???(??):
PDE 3B;EC 3.1.4.17;Phosphodiesterase 3B;(4-Nitrobenzyl)arsonic acid;Phosphodiesterasefrombovinebrain;Phosphodiesterase 3B, Recombinant;3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE;Phosphodiesterase, cyclic 3',5'-nucleotide;Phosphodiesterase 3A from Human, Recombinant
CBNumber:
CB2437361
???:
??? ??:
0
MOL ??:
Mol file

3':5'-??-???????5'-???????????? ??

?? ??
-20°C
??? ??
????? ??
???? ??
bovine heart
Specific Activity
1-5units/mg protein (without added calmodulin)

??

WGK ?? 3
???? ??? 11 - Combustible Solids

3':5'-??-???????5'-???????????? C??? ??, ??, ??

????

? (1) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.

??(2) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 5.0ppm ????? ??.

??(3) ???? : ? ??? 「??? ?? ? ??」 ?????? ?????? ? ????? ?? ??? ?, ?? 1g? 30 ????? ??.

??(4) ???? : ? ??? 「??? ?? ? ??」 ?????? ?????? ? ????? ?? ??? ?, ??(-)??? ??.

??(5) ??? : ? ?? 25g? ??? 「??? ?? ? ??」 ?????? ?????? ? ???? ?? ??? ?, ??(-)??? ??.

????

? ? ??? ?????? ?? ??? ? ??? ????? ??.

??

? ? ??? Penicillium citrinum? ????? ??? ?????. ??, ????, ???? ?? ??? ???, ??? ?? ??? ? ??.

??? ??? ?? ?? ??????? ??? ?????? ????????? ????.

??

For use in calmodulin (P 0270) assay. Activity is reduced to <50% without calmodulin present.

?? ??

Phosphodiesterase (PDE1) exists in two isoforms -PDE1A2 and PDE1B1. The enzyme has a role in the complex interaction between cyclic nucleotides and Ca2+ second-messenger systems.

Clinical Use

Phosphodiesterase-3 (PDE3) is an enzyme responsible for degradation of cAMP to AMP in platelets and blood vessels. Selective cAMP PDE3 inhibitors, such as dipyridamole and cilostazol , inhibit the degradation of cAMP, thereby increasing cellular concentration of cAMP and leading to inhibition of platelet aggregation and vasodilation.

3':5'-??-???????5'-???????????? ?? ?? ? ???

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3':5'-??-???????5'-???????????? ?? ??

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