???-5'-?????, ???? ?
|
|
???-5'-?????, ???? ? ??
- ???
- 300 °C
- ???
- 8 ° (C=2, H2O)
- ?? ??
- 2-8°C
- ???
- water: 100 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
- ??? ??
- ?? ??
- ??
- ???
- ???? ??
- synthetic
- ???
- water: 100mg/mL, clear to very slightly hazy, colorless to very faintly yellow
- ??? ?? ??
- ?? ????
?? ???? - ??
- InChI
- InChI=1/C9H14N3O8P.Na.H/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
- InChIKey
- RCIPNLSOCXMZDD-RFFBCSJBNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,11,r|
- CAS ??????
- 6757-06-8(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 20/21/22-36/37/38 | ||
| ????? | 22-24/25-37/39-36-26 | ||
| WGK ?? | 3 | ||
| F ?????? | 1-10 | ||
| HS ?? | 29349990 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ???? ?? | KE-09353 |
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
| ??·?? ??: |
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| ??????: |
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???-5'-?????, ???? ? C??? ??, ??, ??
????
? (1) ?? : ? ?? 0.5g? ? 10mL? ?? ?, ? ?? ????? ??? ?? ?? ????? ??.
??(2) ?? : ? ??? ???(1→20)? pH? 8.0～9.5??? ??.
??(3) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.
??(4) ? : 「???????」? ???? (2)? ?? ????(2.0ppm ??).
??(5) ??? : ? ??? 0.01N ??(1→50,000)? ?? 250nm, 260nm ? 280nm??? ??? A1, A2 ? A3? ??? ? A1/A2? 0.40～0.52, A3/A2? 1.85～2.20??? ??.
??(6) ?? ????? : 「5''-????????」? ???? (6)? ?? ????.
????
? (1) ? ?? 20mg? 0.01N ?? 100mL? ??? ? ? 10mL? 0.01N ??? ??? 100mL? ? ?? ?? 279±2nm? ?????? ??.
??(2) ? ??? ???(3→10,000) 3mL? ?? 1mL ? ???? 1mL? ??? ?? ??? 30?? ???? ??? ?? ?? ??? ??? ? ???????(1→10) 0.2mL? ??? ????????????(1→1,000) 3mL? ??? ?? ??? 20?? ???? ??? ????.
??(3) ? ??? ???(1→20) 5mL? ??????? 2mL? ?? ?, ??? ??? ????. ?? ?? 7mL? ??? 10?? ?? ?? ????????(1→25)? ??? ??? ?? ????? ? ??? (?)? ??? ????.
??(4) ? ??? ????? ? ????? ??? ????.
???
? ? ?? ? 500mg? ??? ?? 0.01N ??? ?? 1,000mL? ?? ? ? 10mL? 0.01N ??? ??? 250mL? ?? ?????? ??. 0.01N ??? ????? ?? ??? ?? 1cm? ?? 280nm? ???? ??? A? ???? ?? ???? ?? 5''-????????? ??? ???.
??
Cytidine 5'-monophosphate disodium salt (5'-CMPNa2) is an organic sodium salt that can be used as a pharmaceutical active ingredient. 5'-CMPNa2 can be used with UMP-Na2, vitamin B6, lipoic acid, and magnesium lactate dihydrate to prepare a capsule-type compound drug for the treatment of polyneuropathy[1].??? ??
White crystalline powder??
Cytidine 5′-monophosphate disodium salt has been used:- in nucleotide stock solution
- as an ectonucleotidase (ENTase) inhibitor to probe 5′-ENTase activity in cortical neurons
- in in vitro studies to estimate its effect on growth response of selected bacteria strains that dominate the piglets′ small intestine
?? ??
The production method of Cytidine 5'-monophosphate disodium salt comprises the following steps: a. adding cytidine, triethyl phosphate and pyridine into a reaction container respectively, and adjusting the reaction temperature to -15-5°C after mixing evenly, and slowly adding a certain amount of phosphorus oxychloride under the temperature condition, and continuing to stir and react for 10-30h after adding; b. taking samples for HPLC analysis, and when the conversion rate is ≥99%, adding 10-15% ice salt water for hydrolysis, and the hydrolysis temperature is controlled to be 0-5°C, and the hydrolysis time is 10-20h; c. after the hydrolysis is completed, standing and stratifying, removing the organic phase, and obtaining a water layer for standby use; d. adjusting the pH of the water layer to 7.0-8.0 with 30% sodium hydroxide, and then dripping 95% alcohol twice the volume of the solution, precipitating crystals, and filtering to obtain a crude product. e. dissolving the crude product, adding activated carbon for decolorization, and continuing to drip 95% alcohol twice the volume of the solution to precipitate crystals, filtering, rinsing, and drying to obtain the finished product Cytidine 5'-monophosphate disodium salt.??
ChEBI: Disodium cytidine 5'-monophosphate is an organic sodium salt that is the disodium salt of CMP. It has a role as a human metabolite. It contains a cytidine 5'-monophosphate(2-).???-5'-?????, ???? ? ?? ?? ? ???
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?? ??
???-5'-?????, ???? ? ?? ??
???( 429)?? ??
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???-5'-?????, ???? ? ?? ??:
?????????????, ???? ? ???????? ??? ????? ???-5'-?????, ???? ?
Disodium hydrogen phosphate dihydrate
Clodronate disodium Salt
Sodium Monofluorophosphate
Cytidine-5'-triphosphate disodium salt dihydrate
Pamidronate disodium salt
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
2'-Deoxycytidine-5'-monophosphoric acid
2'-Deoxycytidine-5'-monophosphate disodium salt
Cytidine 5’-monophosphate
2',3'-Dideoxycytidine 5'-monophosphate
CYTIDINE 5'-MONOPHOSPHATE SODIUM SALT
CYTIDINE-5'-MONOPHOSPHATE DISODIUM SALT HEXAHYDRATE
CYTIDINE-5'-MONOPHOSPHATE SODIUM SALT, [5'-3H]