VitaMin D4
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VitaMin D4 ??
- ???
- 83-86 °C(lit.)
- ??
- D18 +89.3° (c = 0.47 in acetone)
- ?? ?
- 504.9±29.0 °C(Predicted)
- ??
- 0.96
- ?? ??
- 2-8°C
- ???
- ?????? ???
- ??? ??
- ??
- ?? ?? (pKa)
- 14.74±0.20(Predicted)
- ??
- Off-white to light yellow
- ???
- ???, ??? ???
- InChIKey
- DIPPFEXMRDPFBK-JPWDPSJFSA-N
- SMILES
- [C@H]1(O)CCC(=C)/C(=C\C=C2/CCC[C@@]3(C)[C@@]/2([H])CC[C@@H]3[C@H](C)CC[C@H](C)C(C)C)/C1
- CAS ??????
- 511-28-4(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T+ | ||
|---|---|---|---|
| ?? ???? ?? | 24/25-26-48/25 | ||
| ????? | 28-36/37 | ||
| ????(UN No.) | UN 2811 6.1/PG 2 | ||
| WGK ?? | 2 | ||
| RTECS ?? | VS2900000 | ||
| F ?????? | 8-10-23 | ||
| ???? ??? | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 3 Dermal Acute Tox. 3 Oral STOT RE 1 Oral |
VitaMin D4 C??? ??, ??, ??
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Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.??? ??
Pale Yellow Oil??
Vitamin D4 is the active analogue of Vitamin D.Biological Functions
Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.Source
Vitamin D is a 9,10-secosteroid and 6 forms have been identified. The importance of vitamin D in bone (calcium homeostasis) is well established, and vitamin D has been the subject of increased attention in recent years for its role in muscle function, immunology, heart and cardiovascular disease, cancer, and insulin secretion. The vitamin D4 precursor 22,23-dihydroergosterol was present in all mushroom composites. The levels were not correlated with vitamin D4, but differed among species. Enoki mushrooms had a notably higher 22,23-dihydroergosterol content, with an average of 16.5 mg/100g compared to 4.49–8.89 mg/ 100 g in other types of mushrooms.VitaMin D4 ?? ?? ? ???
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VitaMin D4 ?? ??
???( 208)?? ??
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|---|---|---|---|---|---|
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