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110235-47-7
???:
?????
???(??):
?????
???:
MEPANIPYRIM
???(??):
FRUPICA;MEPANIPYRIM;Mepanioyrim;mepanipyrin;Mepanipyrim 50;Mepanipyrim-D5;Mepanipyrim [iso];MEPANIPYRIM STANDARD;Mepanipyrim in Acetonitrile;Mepanipyrim@100 μg/mL in AcCN
CBNumber:
CB3230301
???:
C14H13N3
??? ??:
223.27
MOL ??:
110235-47-7.mol
MSDS ??:
SDS

????? ??

???
125-126° (Maeno); also reported as 132.8° (Hayashi)
?? ?
418.2±47.0 °C(Predicted)
??
1.16±0.1 g/cm3(Predicted)
???
2.32 x l0-5 Pa (20 °C)
???
131 °C
?? ??
0-6°C
???
?????(?? ???), ???(?? ???)
?? ?? (pKa)
4.5 (est. base)
???
3.1mg l-1(20°C)
??
???? ?????
Henry's Law Constant
6.0×102 mol/(m3Pa) at 25℃, Maniere et al. (2011)
?? ??
??
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InChI
1S/C14H13N3/c1-3-7-13-10-11(2)15-14(17-13)16-12-8-5-4-6-9-12/h4-6,8-10H,1-2H3,(H,15,16,17)
InChIKey
CIFWZNRJIBNXRE-UHFFFAOYSA-N
SMILES
CC#Cc1cc(C)nc(Nc2ccccc2)n1
LogP
3.280
EPA
Mepanipyrim (110235-47-7)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? N,Xn
?? ???? ?? 51/53-50/53-40
????? 60-61-46-36/37
????(UN No.) UN3077 9/PG 3
WGK ?? 2
RTECS ?? UV6261540
???? ??? 11 - Combustible Solids
Hazard Classifications Aquatic Acute 1
Aquatic Chronic 1
Carc. 2
?? LD50 in mice, rats, bobwhite, mallard (mg/kg): >5000, >5000, >2250, >2250 orally; in rats (mg/kg): >2000 dermally; LC50 in bluegill, rainbow trout (mg/l): 3.8, 3.1 (Maeno)
???? ?? 97-3-439
????(GHS): Health Hazard (GHS08)Environment (GHS09)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H351 ?? ??? ??? ??? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??) ??? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? P273, P391, P501
??????:
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P273 ???? ???? ???.
P280 ????/???/???/?????? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P391 ???? ????.
P405 ???? ?????.

????? C??? ??, ??, ??

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Mepanipyrim is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries.

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ChEBI: A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying additional methyl and 1-propynyl substituents at positions 4 and 6 respectively. A fungicide used to control a wide range of diseases including grey mou d on strawberries, tomatoes and cucumabers, and scab on apples and pears.

?? ?? ??

By tomato seedlings, 14C-mepanipyrim is biotransformed via the pathways including elimination of the phenyl group, hydroxylation of the propynyl moiety, and hydroxylation at the phenyl ring to yield several kinds of metabolite, and 2- and 4-[4-methyl-6- (1-propynyl)pyrimidin-2-ylamino]phenols, 1-(2-anilino-6- methylpyrimidin-4-yl)-2-propanol, and 4-methyl-6-(1- propynyl)pyrimidin-2-ylamine are tentatively identified as major metabolites. In soils under laboratory conditions, 14C-mepanipyrim undergoes degradation to give the degradation products and the main pathway is elimination of the phenyl group.

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