ChemicalBook >?? ???? >1,2-?????,N,N'-??(?????)-,?????????
1,2-?????,N,N'-??(?????)-,?????????
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1,2-?????,N,N'-??(?????)-,????????? ??
- ?? ??
- -20°C
- ???
- <46.55mg/ml in DMSO;insoluble in H2O
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- InChI
- 1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
- InChIKey
- YRQCDCNQANSUPB-UHFFFAOYSA-N
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1,2-?????,N,N'-??(?????)-,????????? C??? ??, ??, ??
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AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7). It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR). It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM. AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson''s disease induced by 6-hydroxy dopamine (6-OHDA; ).1,2-?????,N,N'-??(?????)-,????????? ?? ?? ? ???
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1,2-?????,N,N'-??(?????)-,????????? ?? ??
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