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6-(????????)???-3-????

6-(????????)???-3-????
6-(????????)???-3-???? ??? ???
?? ??:
231291-22-8
???:
6-(????????)???-3-????
???(??):
6-(????????)???-3-????
???:
6-(Trifluoromethyl)nicotinic acid
???(??):
3,5-Dichloropyrazine-2-carboxylic acid;6-(Trifluoromethyl)-3-pyridinecarboxylic acid;6-(TrifL;6-Trifluoromethyl;RARECHEM AL BO 1001;6-(TRIFLUOROMETHYL)PYRIDI;6-Trifluoromethylnicotic acid;TRIFLUOROMETHYL NICOTINIC ACID;6-(TRIFLUROMETHYL)NICOTINICACID;6- threefluorine Methylnicotinate
CBNumber:
CB3440751
???:
C7H4F3NO2
??? ??:
191.11
MOL ??:
231291-22-8.mol

6-(????????)???-3-???? ??

???
193-197 °C(lit.)
?? ?
259.3±40.0 °C(Predicted)
??
1.484±0.06 g/cm3(Predicted)
?? ??
Inert atmosphere,Room Temperature
???
??????(??), ???(??)? ???
??? ??
??
??? ??
??? ??
?? ?? (pKa)
2.96±0.10(Predicted)
??
??????? ????????
InChI
InChI=1S/C7H4F3NO2/c8-7(9,10)5-2-1-4(3-11-5)6(12)13/h1-3H,(H,12,13)
InChIKey
JNYLMODTPLSLIF-UHFFFAOYSA-N
SMILES
C1=NC(C(F)(F)F)=CC=C1C(O)=O
CAS ??????
231291-22-8(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26-36
WGK ?? 3
?? ?? IRRITANT
HS ?? 29333990
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
NFPA 704
0
2 0

6-(????????)???-3-???? C??? ??, ??, ??

??? ??

6-Trifluoromethylnicotinic acid is a white powder with a melting point of 193-197 °C. It has a boiling point of 259.3℃ at 760 mmHg. Its density is 1.484 g/cm3. Its flash point, refractive index and vapor pressure are 110.6℃, 1.475 and 0.007mmHg at 25°C, respectively.

??

6-(Trifluoromethyl)nicotinic acid can be used to prepare Raf inhibitors to treat cancer.

?? ??

6-(Trifluoromethyl)nicotinic acid is a key intermediate of many fluorine-containing drugs.

???

6-(Trifluoromethyl)nicotinic acid causes skin irritation and serious eye irritation.

6-(????????)???-3-???? ?? ?? ? ???

???

?? ??


6-(????????)???-3-???? ?? ??

???( 409)?? ??
??? ?? ??? ?? ?? ? ??
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6-(????????)???-3-???? ?? ??:

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