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Betamethasone 17,21-dipropionate

Betamethasone 17,21-dipropionate ??? ???
?? ??:
5593-20-4
???:
Betamethasone 17,21-dipropionate
???(??):
BETAMETHASONE DIPROPIONATE;BetaMethasone dipropionat;diprolene;diprosone;Betamethasone 17;Betamethasonediproprionate;Betamethasone dipropionate for system suitability;S 3440;Psorion;Maxivate
CBNumber:
CB3676725
???:
C28H37FO7
??? ??:
504.6
MOL ??:
5593-20-4.mol

Betamethasone 17,21-dipropionate ??

???
178 °C
??
D26 +65.7° (dioxane)
?? ?
603.2±55.0 °C(Predicted)
??
1.1481 (estimate)
???
69 ° (C=1, Dioxane)
?? ??
2-8°C
???
??? ?? ?? ???, ???? ??????? ? ??, ????? ?? ?? ????(96%).
??? ??
Solid
?? ?? (pKa)
12.87±0.70(Predicted)
??
???? ?? ???
Merck
1180
?? ??
???(???)
InChIKey
CIWBQSYVNNPZIQ-JCOVECCMSA-N
SMILES
C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS ??????
5593-20-4(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????? 22-24/25
WGK ?? 2
RTECS ?? TU4058000
HS ?? 29372290
???? ??? 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Repr. 1B
STOT RE 2
?? LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82
????(GHS): Health Hazard (GHS08)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H373 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ?? ?? ???? ?? - ?? ?? ?? 2 ?? P260, P314, P501
??????:
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P260 ??·?·??·???·??·...·????? ???? ???.
P280 ????/???/???/?????? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.

Betamethasone 17,21-dipropionate C??? ??, ??, ??

??? ??

Betamethasone 17,21-dipropionate is Pale Yellow Foam

??

Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.

??

Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.

Betamethasone 17,21-dipropionate ?? ?? ? ???

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Betamethasone 17,21-dipropionate ?? ??

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Betamethasone 17,21-dipropionate ?? ??:

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