Nandrolone phenylpropionate
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Nandrolone phenylpropionate ??
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- 85-87°C
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- D +58° (chloroform)
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- 487.61°C (rough estimate)
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- 1.0140 (rough estimate)
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- 1.5460 (estimate)
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- Controlled Substance, -20°C Freezer
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- DMSO : 100 mg/mL (245.97 mM; Need ultrasonic)
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- InChIKey
- UBWXUGDQUBIEIZ-QNTYDACNSA-N
- SMILES
- C[C@]12CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@H]2OC(=O)CCC1C=CC=CC=1 |&1:1,4,6,16,18,22,r|
- CAS ??????
- 62-90-8(CAS DataBase Reference)
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| ??? ?? | Xn | ||
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| ?? ???? ?? | 20/21/22-40 | ||
| ????? | 23-36 | ||
| WGK ?? | WGK 3 | ||
| RTECS ?? | KG7995000 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Carc. 2 Repr. 1B |
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| ?? | LD50 intraperitoneal in mouse: > 1gm/kg |
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| ?? ?: | Danger | ||||||||||||||
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Nandrolone phenylpropionate C??? ??, ??, ??
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Anabolic steroid; androgen.World Health Organization (WHO)
Nandrolone phenylpropionate, an anabolic steroid, was introduced in 1959. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible promotion of products containing anabolic steroids for malnourished children. Higher dosage preparations of nandrolone phenylpropionate remain available in many countries, including Bangladesh, for several highly specific but limited indications that apply to patients with chronic debilitating and emaciating diseases, particularly associated with neoplasia and some types of aplastic anaemia.Synthesis
Nandrolone phenylpropionate is prepared by reacting anhydrous MeCN with a mixture of 3-phenylpropanoic acid, aryneprecursor, nandrolone CsF, K2CO3, and 18-crown-6 in 70 in an oil bath.Add anhydrous MeCN (0.5 mL) to a mixture of 3-phenylpropanoic acid (30.0 mg, 0.2 mmol, 1.0 equiv), aryneprecursor (119.2 mg, 0.4 mmol, 2.0 equiv), nandrolone (82.3 mg, 0.3 mmol, 1.5 equiv), CsF (182.3 mg, 1.2 mmol, 6.0 equiv), K2CO3 (82.9 mg, 0.6 mmol, 3.0 equiv), and 18-crown-6 (158.6 mg, 0.6 mmol, 3.0 equiv). Warm the mixture to 70 in an oil bath and stir at this temperature for8 hours. Remove all the volatiles directly on rotary evaporator. Purify by flash column chromatography with pet ether:EtOAc = 20:1. 1H NMR (400 MHz, CDCl3) | 7.31-7.26(m,2H), 7.23-7.17(m,3H), 5.83 (s, lH), 4.65-4.58(m, lH), 2.95(t, J= 8.0 Hz,2H), 2.64(t, J= 8.0 Hz,2H), 2.51-2.36(m, 2H), 2.31-2.04(m, 5H), 1.86-1.79(m, 2H), 1.72-1.61 (m, 2H), 1.57-1.00(m, 8H),0.90-0.81(m, 1H), 0.79 (s, 3H)ppm.
Fig The synthetic method 1 of Nandrolone phenylpropionate
Nandrolone phenylpropionate ?? ?? ? ???
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Nandrolone phenylpropionate ?? ??
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