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4-(????????)?????

4-(????????)?????
4-(????????)????? ??? ???
?? ??:
1544-86-1
???:
4-(????????)?????
???(??):
4-(????????)?????
???:
4-(Difluoromethoxy)nitrobenzene
???(??):
BUTTPARK 45\10-48;α,α-Difluoro-p-nitroanisole;Anisole,α,α-difluoro-p-nitro-;4-(DIFLUOROMETHOXY)NITROBENZENE;p-Nitrophenyldifluoromethylether;Difluoromethyl4-nitrophenylether;1-(DIFLUOROMETHOXY)-4-NITROBENZENE;4-(Difluoromethoxy)nitrobenzene98%;4-(Difluoromethoxy)nitrobenzen, 98%;4-NITRO-ALPHA,ALPHA-DIFLUOROANISOLE
CBNumber:
CB3714535
???:
C7H5F2NO3
??? ??:
189.12
MOL ??:
1544-86-1.mol
MSDS ??:
SDS

4-(????????)????? ??

???
37-40 °C (lit.)
?? ?
108 °C
??
1.384±0.06 g/cm3(Predicted)
???
>230 °F
?? ??
2-8°C
??? ??
powder to lump
??
Light yellow to Brown to Dark green
???
31.0 to 34.0 ℃
InChI
1S/C7H5F2NO3/c8-7(9)13-6-3-1-5(2-4-6)10(11)12/h1-4,7H
InChIKey
SVGGBARCOQPYMV-UHFFFAOYSA-N
SMILES
[O-][N+](=O)c1ccc(OC(F)F)cc1
CAS ??????
1544-86-1(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn,Xi
?? ???? ?? 22-36/37/38
????? 26-36/37
????(UN No.) 3276
WGK ?? 3
?? ?? IRRITANT
HS ?? 29049090
???? ??? 13 - Non Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P280 ????/???/???/?????? ?????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
1
2 0

4-(????????)????? C??? ??, ??, ??

??? ??

Pale Yellow Crystal.

??

4-(Difluoromethoxy)nitrobenzene is an industrial chemical that can be used to make 4-fluoro-3-pyridinol (F3P), a compound that has potential as a new drug for the treatment of cancer. The synthesis of F3P begins with the reaction of 4-(difluoromethoxy)nitrobenzene and potassium hydroxide in methanol, which yields 4-fluoro-3-hydroxypyridine. This product is then reacted with ammonia gas and pyridine to yield F3P. The final step involves heating the product at high temperature with nitric acid, which yields nitrobenztriazole.

?? ??

4-(Difluoromethoxy)nitrobenzene (1-(difluoromethoxy)-4-nitrobenzene) can be synthesized by reacting 4-nitrophenol with KOH, water and methanol.

4-(????????)????? ?? ?? ? ???

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