(SAR9,MET(O2)11)-SUBSTANCE P
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(SAR9,MET(O2)11)-SUBSTANCE P ??
- ??
- 1.43±0.1 g/cm3(Predicted)
- ?? ??
- −20°C
- ???
- H2O : 50 mg/mL (35.88 mM; Need ultrasonic)
- ?? ?? (pKa)
- 13.31±0.20(Predicted)
- ??? ??
- ????? ??.
- ??
- White to off-white
- ???
- Soluble to 1 mg/ml in water
- ???
- H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2
- InChIKey
- OUPXSLGGCPUZJJ-UHFFFAOYSA-N
??
| WGK ?? | 3 | ||
|---|---|---|---|
| ???? ??? | 11 - Combustible Solids |
(SAR9,MET(O2)11)-SUBSTANCE P C??? ??, ??, ??
??
[Sar9,Met(O2)11]-Substance P is a potent and selective NK1 tachykinin receptor agonist (1). The NK1 tachykinin receptor is a member of the G-protein coupled receptor family and can be found in neurons, brainstem, and vascular endothelial cells (2,3). NK1 tachykinin receptor is a therapeutic target for pancreatic cancer (4).Biochem/physiol Actions
Highly selective NK-1 receptor agonist.(SAR9,MET(O2)11)-SUBSTANCE P ?? ?? ? ???
???
?? ??
(SAR9,MET(O2)11)-SUBSTANCE P ?? ??
???( 117)?? ??
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(SAR9,MET(O2)11)-SUBSTANCE P ?? ??:
acetyl-[arg6, sar9, met(o2)11]-substance p fragment 6-11
[AcArg6,Sar9,Met(O2)11]substance P,[Ac-Arg6,Sar9,Met(O2)11]substance P(6-11)
[βAla4,Sar9,Met(O2)11]substance P(4-11)
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET-NH2
SUBSTANCE P (4-11)
SUBSTANCE P (7-11)
SUBSTANCE P (5-11)
(SAR9,MET(O2)11)-SUBSTANCE P
SUBSTANCE P, (9-SAR, 11-MET(O2)), [2-PROLYL-3,4-3H]-
GLY-LEU-MET-NH2
SUBSTANCE P (6-11)
substance P (3-11)
SUBSTANCE P (2-11)
SUBSTANCE P