Epothilone D
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Epothilone D ??
- ???
- 63-66°C
- ??
- D22 -61.3° (c = 2.5 in methanol)
- ?? ?
- 663.7±55.0 °C(Predicted)
- ??
- 1.084±0.06 g/cm3(Predicted)
- ?? ??
- -20°C Freezer
- ???
- DMSO? ???
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 13.47±0.70(Predicted)
- ??
- ???? ?????
- InChIKey
- XOZIUKBZLSUILX-GIQCAXHBSA-N
- SMILES
- O1[C@H](/C(/C)=C/C2=CSC(C)=N2)CC=C(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC1=O |t:13|
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Epothilone D C??? ??, ??, ??
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Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions. They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models. Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice. Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice. Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss. Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.??? ??
White Foam??
ChEBI: An epithilone that is epithilone C in which the hydrogen at position 13 of the oxacyclohexadec-13-ene-2,6-dione macrocycle has been replaced by a methyl group.Epothilone D ?? ?? ? ???
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Epothilone D ?? ??
???( 151)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Accendatech Co., Ltd. | +8613132578992 |
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| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 |
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| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
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| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29792 | 58 |
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oled@richest-group.com | CHINA | 5600 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 28509 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 |
info@afinechem.com | China | 15083 | 58 |
Epothilone D ?? ??:
?????
BOC-3-ENDO-AMINOBICYCLO[2.2.1]HEPTANE-2-ENDO-CARBOXYLIC ACID
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole
Tigecycline
MITHRAMYCIN A
Abiraterone
Daptomycin
Geldanamycin
RIFAMYCIN SV
Vinorelbine tartrate
Epothilone B
Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9-tetramethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)-
Epothilone A
epothilone E
(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester
2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel
4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID
6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE