ChemicalBook >?? ???? >3-??????
3-??????
|
|
3-?????? ??
- ???
- 233-235°C
- ?? ?
- 569.2±50.0 °C(Predicted)
- ??
- 1.718±0.06 g/cm3(Predicted)
- ?? ??
- -20°C
- ???
- DMSO(?? ???), ???(?? ???), ?(?? ???)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 4.50±1.00(Predicted)
- ??
- ???? ?? ?????
- ?? ??
- 35.3°(C=1.00g/100ml H2O)
- InChI
- InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
- InChIKey
- CBOKZNLSFMZJJA-FNMQVXAUNA-N
- SMILES
- [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r|
- LogP
- -1.693 (est)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| RTECS ?? | UV1148000 |
|---|
| ????(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ?? ?: | Warning | ||||||||||||||||||||||||||||
| ??·?? ??: |
|
||||||||||||||||||||||||||||
| ??????: |
|
3-?????? C??? ??, ??, ??
??
3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].??
Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.3-?????? ?? ?? ? ???
???
?? ??
3-?????? ?? ??
???( 92)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD | 0371-55159968 18137130222 |
haifeng.zhang@pannacean.com | China | 715 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2994 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10403 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 |
laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +8616314854226 |
inquiry@bocsci.com | United States | 19853 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 |
sales@newcanbio.com | China | 9985 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39037 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 |
nickzhang@hangyubiotech.com | China | 9942 | 58 |
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
3-?????? ?? ??:
??????-1-???? ??????-1,2-????? N-?????????? N,N-???????????
3-Methylamino-1,2-propanediol
N-Methyl-N-vinylacetamide
1-Methyl-2-pyridone
N,N-Dimethylallylamine
N-ETHYL ACRYLAMIDE
N-(HYDROXYMETHYL)ACETAMIDE
N-VINYLACETAMIDE 97
4-DIMETHYLAMINO-1-BUTANOL
N-hydroxymethyl-N-methylformamide
N-N-BUTYLACRYLAMIDE
(S)-3-(Dimethylamino)-1,2-propanediol
3-Deazauridine
3-Acryloylamino-1-propanol solution, 50% in water
N-(1-ISOPROPOXYETHYL)ACETAMIDE