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?? ??:: 151879-73-1

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???:: aprinocarsen

???(??):: Ly900003;Ly 900003;Isis 3521;Affinitak;aprinocarsen;Aprinocarsen [inn];DNA d(P-thio)(G-T-T-C-T-C-G-C-T-G-G-T-G-A-G-T-T-T-C-A) (ACI);Deoxyribonucleic acid, D(p-thio)(A-C-T-T-T-G-A-G-T-G-G-T-C-G-C-T-C-T-T-G);Guanosine, 2'-deoxy-p-thioadenylyl-(5'-3')-2'-deoxy-p-thiocytidylyl-(5'-3')-p-thiothymidylyl-(5'-3')-p-thiothymidylyl-(5'-3')-p-thiothymidylyl(5'-3')-2'-deoxy-p-thioguanylyl-(5'-3')-2'-deoxy-p-thioadenylyl-(5'-3')-2'-deoxy-p-thioguanylyl-(5'-3')-p-thiothymidylyl-(5'-3')-2'-deoxy-p-thioguanylyl-(5'-3')-2'-deoxy-p-thioguanylyl-(5'-3')-p-thiothymidylyl-(5'-3')-2'-deoxy-p-thiocytidylyl-(5'-3')-2'-deoxy-p-thioguanylyl-(5'-3')-2'-deoxy-p-thiocytidylyl-(5'-3')-p-thiothymidylyl-(5'-3')-2'-deoxy-p-thiocytidylyl-(5'-3')-p-thiothymidylyl-(5'-3')-p-thiothymidylyl-(5'-3')-2'-deoxy-

CBNumber:: CB41856022

???:: C196H249N68O105P19S19

??? ??:: 6435.203319

MOL ??:: 151879-73-1.mol

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Treatment of non-small cell lung cancer (antisense oligonucleotide; protein kinase C-alpha inhibitor).

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Affinitak (Isis).

Clinical Use

Aprinocarsen is a phosphorothioate antisense agent targeted against protein kinase Cα, a protein that is implicated in malignant transformation and proliferation. It showed activity in Phase I and Phase II clinical trials against nonsmall-cell lung cancer when used in combination with cisplatin or the combination of cisplatin and gemcitabine.

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Qingdao Haizhi Weiyuan Biotechnology Co., Ltd.	18317699790 18317699790	l202008112023@163.com	China	8675	58

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