4-???????
|
|
4-??????? ??
- ???
- 237-240 °C(lit.)
- ?? ?
- 295.67°C (rough estimate)
- ?? ??
- 700kg/m3
- ??
- 1.61
- ???
- 1.6280 (estimate)
- ???
- 237 °C
- ?? ??
- Store below +30°C.
- ???
- 0.42g/L
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 3.41(at 25℃)
- ??
- ???
- ??????(pH)
- 3.1 (0.42g/l, H2O, 20℃)(saturated solution)
- ???
- 26°C?? <0.1g/100mL
- Merck
- 14,6589
- BRN
- 973593
- Specific Activity
- 50-60 mCi/mmol
- Concentration
- 0.1 mCi/ml
- Solvent
- Ethanol
- Henry's Law Constant
- 3.2×103 mol/(m3Pa) at 25℃, Abraham and Jr. (2019)
- ???
- ????. ?? ??. ?? ???, ????, ???? ???? ????.
- InChI
- 1S/C7H5NO4/c9-7(10)5-1-3-6(4-2-5)8(11)12/h1-4H,(H,9,10)
- InChIKey
- OTLNPYWUJOZPPA-UHFFFAOYSA-N
- SMILES
- OC(=O)c1ccc(cc1)[N+]([O-])=O
- LogP
- 1.890
- CAS ??????
- 62-23-7(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-41-36 | ||
| ????? | 26-39-24/25 | ||
| WGK ?? | 1 | ||
| RTECS ?? | DH5075000 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29163900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Carc. 2 Eye Irrit. 2 Muta. 2 Repr. 2 Skin Irrit. 2 |
||
| ?? ?? ??? | 62-23-7(Hazardous Substances Data) | ||
| ?? | LD50 orally in Rabbit: 1960 mg/kg | ||
| ???? ?? | KE-25976 |
4-??????? C??? ??, ??, ??
??? ??
light yellow crystalline powder??
4-Nitrobenzoic Acid is used in the synthesis of anti-Trypanosoma cruzi agents in the treatment of chagas disease.??
ChEBI: A nitrobenzoic acid having the nitro group at the 4-position.?? ??
p-Nitrobenzoic acid is produced commercially by the oxidation of 4-nitrotoluene with molecular oxygen. Oxidation with 15 % nitric acid at 175 ℃ produces the acid in 88.5 % yield. An interesting method involves the nitration and subsequent oxidation of polystyrene. This method uses the steric hindrance of the polymer chain to improve the para to ortho ratio of the product.?? ??
Odorless pale yellow crystals.??? ?? ??
Insoluble in water.?? ???
p-Nitrobenzoic acid is incompatible with strong oxidizers. p-Nitrobenzoic acid is also incompatible with strong bases (potassium hydroxide). p-Nitrobenzoic acid may react with cyanides.????
p-Nitrobenzoic acid is combustible.Toxicology
Among various nitroaromatics, 4-nitrobenzoic acid (4-NBA) is one of the simplest and basic derivates of the explosives. Moreover, 4-NBA harms human health and causes severe water and atmosphere pollution. 4-Nitrobenzoic acid is stable, toxic, and non-biodegradable. US/Zn0 was found to degrade more than 85% of 4-nitrobenzoic acid in 30 min. There was an apparent synergistic effect between ultrasound and Zn[1-2].Purification Methods
Purify it as for 3-nitrobenzoic acid above. The amide has m 201.6o (from H2O). [Beilstein 9 III 1537, 9 IV 1072.]4-??????? ?? ?? ? ???
???
?? ??
Benoxinate Hydrochloride
4-Nitrobenzonitrile
6-???????
p-???????????
N-(p-Aminobenzoyl)glutamic acid
Methyl 4-nitrobenzoate
Methyl 4-aminobenzoate
4-??????????
2-????????4-????????
4-??????
4-Aminobenzamidine dihydrochloride
Butethamine
ISOPROPYL 4-AMINOBENZOATE
??p-????????
?????
4-AMINOBENZANILIDE
3,4-??????? ?
???? ?????????
N-(2-(2-??????)??)-4-????????
P-?????????
4-Aminophthalic acid
????????
????
4-??????? ?? ??
???( 885)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 |
info@dycnchem.com | China | 52693 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 |
sale@simagchem.com | China | 17339 | 58 |
| Shandong Believe Chemical PTE.LTD | +86-18553607090 +8618906362908 |
1093908296@qq.com | China | 1660 | 58 |
| Shanghai Xin Cheng Yue Chemical Co.,Ltd | +86-021-57806787 +86-17701820076 |
wuziwei@xinyuefirm.com | China | 31 | 58 |
| Guangzhou Tosun Pharmaceutical Ltd | +86-020-61855200-902 +86-18124244216 |
info@upharm.cn | China | 896 | 58 |
| Zouping mingyuan import & export trading co., ltd | +86-0543-2240078 +8618364991597 |
myzhao793@163.com | China | 981 | 58 |
| Anhui Royal Chemical Co., Ltd. | +86-025-86655873 +86-13962173137 |
marketing@royal-chem.com | China | 201 | 55 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 |
Sibel@chuanghaibio.com | China | 8737 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 |
1097@dideu.com | China | 3989 | 58 |
| Nanjing Hike Biological Technology CO. Ltd. | +86-025-52110956; +8613814852963 |
sales@njhkchem.com | China | 8 | 58 |