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(4-?????)(????????)???????????
(4-?????)(????????)??????????? ??? ???
?? ??:
76541-72-5
???:
(4-?????)(????????)???????????
???(??):
(4-?????)(????????)???????????
???:
SR 202
???(??):
SR 202;MIFOBATE;Clenicor;claniclor;SR-202 >=98% (HPLC), crystalline;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate;DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE;(4-Chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate;[(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate, Mifobate
CBNumber:
CB4285085
???:
C11H17ClO7P2
??? ??:
358.65
MOL ??:
76541-72-5.mol

(4-?????)(????????)??????????? ??

?? ?
436.6±45.0 °C(Predicted)
??
1.355±0.06 g/cm3(Predicted)
?? ??
Inert atmosphere,Store in freezer, under -20°C
???
DMSO: 5mg/mL ? ???
??? ??
?? ??
??
???
???
?? 100mM?? ???
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????? 22-24/25
WGK ?? 2
RTECS ?? TB8817000
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

(4-?????)(????????)??????????? C??? ??, ??, ??

??

Anti-atherosclerotic.

???

Clenicor (Symphar S.A.,Switzerland).

???? ??

Selective PPAR γ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPAR γ transcriptional activity (IC 50 = 140 μ M) without affecting ligand-stimulated PPAR α , PPAR β or FXR transcriptional activity. Inhibits PPAR γ -dependent adipocyte differentiation and growth in vitro and in vivo . Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo .

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???( 77)?? ??
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(4-?????)(????????)??????????? ?? ??:

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