ChemicalBook >?? ???? >(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
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(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol ??
- ???
- 123-128°C (dec.)
- ?? ?
- 508.6±60.0 °C(Predicted)
- ??
- 1.42±0.1 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- ?????(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 11.54±0.29(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?????
- ?? ??
- ???(???)
- InChI
- InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3
- InChIKey
- BCEHBSKCWLPMDN-UHFFFAOYSA-N
- SMILES
- C(O)(CN1N=CN=C1)(C(C)C1=NC=NC=C1F)C1C=CC(F)=CC=1F
??
| WGK ?? | WGK 3 | ||
|---|---|---|---|
| HS ?? | 2933997500 | ||
| ???? ??? | 11 - Combustible Solids |
(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol C??? ??, ??, ??
??
(2RS,3RS)α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (Voriconazole USP Related Compound A), is a derivative of Voriconazole (V760000), which is a triazole antifungal medication that is generally used to treat serious fungal infections.(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol ?? ?? ? ???
???
3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
?? ??
(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol ?? ??
???( 106)?? ??
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(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol ?? ??:
????? ??? ????? ??????? 2-???? ??? ??(I) ??????
4-Ethyl-5-fluoropyrimidine
Voriconazole
1-Butanesulfonic acid, 4-hydroxy-, methyl ester
Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI)
Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro-
2-Chloro-2',4'-difluoroacetophenone
1,2,4-Triazole
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
Voriconazole Impurity 53
6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine
Voriconazole Impurity 16