ChemicalBook >?? ???? >????B
????B
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- 5461 -106.3° (1N HCl)
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- Solid
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- White to light yellow
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Polymyxin B was isolated by Wellcome Research Laboratories, in 1949, from the mixture of polymyxins A, B, C, and D produced byBacillus polymyxa. It was later separated into the major component, B1, and the minor component, B2. Polymyxin B is a basic polypeptide and shows strong activity against gram-negative bacteria, but its activity against gram-positive bacteria, Mycobacterium, and fungi is weak. Because of its toxicity, it is used carefully by intramuscular injection for resistant Pseudomonas aeruginosa infections, e.g., sepsis. Polymyxin B is used orally to sterilize the gut in leukemic patients, intraspinally for meningitis, or topically.??
Antibacterial Aerosporin.??
ChEBI: A polymyxin having a 6-methylheptanoyl group at the amino terminus.?? ?? ??
Active against Gram-negative bacteria, Polymyxin B is a mixture of Polymyxin B1 and B2. Sensitization occurs by topical, ophthalmic, and otic preparations. Cosensitization is frequent with other topical antibiotics like neomycin or bacitracin.????B ?? ?? ? ???
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Ethyl isocyanoacetate
Benzyl isocyanide
N-BUTYLISOCYANIDE
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
PHENYLSELENOL
SALCOMINE
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
Tris(2,4-pentanedionato)chroMiuM(III)
TERT-BUTYL ISOCYANIDE
METHYL ISOCYANOACETATE