???-3
|
|
???-3 ??
- ???
- >132oC (dec.)
- ??
- 1.36±0.1 g/cm3(Predicted)
- ?? ??
- -20°C
- ???
- DMSO: 20mg/mL, ???
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 14.35±0.20(Predicted)
- ??
- ???
- ???
- ??? ?? ?????? 2? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 1?? ?? ??? ? ????.
- InChIKey
- BDUHCSBCVGXTJM-UHFFFAOYSA-N
- SMILES
- N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O |&1:20,28,r|
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
???-3 C??? ??, ??, ??
??
(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.Biochem/physiol Actions
Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.???-3 ?? ?? ? ???
???
?? ??
???-3 ?? ??
???( 192)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 21193 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32467 | 58 |
| BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; |
sales@sarms4muscle.com | China | 10473 | 58 |
| Alfa Chemistry | +1-5166625404; |
Info@alfa-chemistry.com | United States | 20405 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 |
market18@leapchem.com | China | 24597 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
???-3 ?? ??:
Nutlin-3b
Nutlin 3a
ZM 447439
Imatinib mesylate
Sunitinib Malate
Cantharidin
2-Ethoxybenzamidine hydrochloride
1-(2-METHOXYBENZYLAMINO)-2-(4-CHLOROPHENYL)ETHANE
NUTLIN-3
2,4-DIMETHOXY-BENZAMIDINE
PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE
meso-1,2-Bis(4-chlorophenyl)ethylenediamine
CHEMBRDG-BB 5543528
CHEMBRDG-BB 5570316
2,4-DIMETHOXY-BENZAMIDINE HCL
2-(4 5-DIHYDRO-1H-IMIDAZOL-2-YL)PHENOL