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?? ??:: 135531-86-1

???:: ????

???(??):: ????

???:: camalexin

???(??):: camalexin;Camalexine;Camalexin >=98% (HPLC);Camalexin, 10 mM in DMSO;2-(1H-indol-3-yl)thiazole;3-(Thiazol-2-yl)-1H-indole;1H-Indole, 3-(2-thiazolyl)-;2-(1H-indol-3-yl)-1,3-thiazole;3-(1,3-Thiazol-2-yl)-1H-indole;3-(1,3-Thiazol-2-yl)-1H-indole, camalexin

CBNumber:: CB51384054

???:: C11H8N2S

??? ??:: 200.26

MOL ??:: 135531-86-1.mol

MSDS ??:: SDS

?? ?? 66

???? ??

?? ?: 424.8±47.0 °C(Predicted)

??: 1.336±0.06 g/cm3(Predicted)

?? ??: 2-8°C

???: DMSO: ???20mg/mL, ??

?? ?? (pKa): 15.49±0.30(Predicted)

??? ??: ??

??: ???? ?? ????

InChI: 1S/C11H8N2S/c1-2-4-10-8(3-1)9(7-13-10)11-12-5-6-14-11/h1-7,13H

InChIKey: IYODIJVWGPRBGQ-UHFFFAOYSA-N

SMILES: C12=CC=CC=C1NC=C2C3=NC=CS3

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	Xn,Xi
?? ???? ??	22-36/37/38
?????	26-36/37/39-45
WGK ??	3
???? ???	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

????(GHS):

?? ?:

Warning

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??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

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P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

NFPA 704

	0
2		0

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Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC₅₀s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC₅₀ = 74.0 μM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.

??

Camalexin has been used in quantification and tolerance assays in Arabidopsis thaliana leaves.

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ChEBI: An indole phytoalexin that is indole substituted at position 3 by a 1,3-thiazol-2-yl group.

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