2-(Trimethylsilyl)ethanol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R10:Entzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
CLEAR COLOURLESS LIQUID
Physikalische Eigenschaften
bp 50–52 °C/10 mmHg, 71–73 °C/35 mmHg;
d 0.825 g cm3.
Verwenden
2-(Trimethylsilyl)ethanol is a protecting reagent for carboxyl, phosphoryl, hydroxyl, and amino
groups. It participates in the reactions of Phenol and Acid Protection, Alcohol Protection, Hemiacetal Protection, Amine Protection, Enol Ether Synthesis, Carbohydrate Chemistry etc.
synthetische
Three methods of preparation have been
reported: (a) from the treatment of ethyl bromoacetate with
zinc followed by the reaction with chlorotrimethylsilane1 and
subsequent reduction of the resultant ethyl trimethylsilylacetate
with lithium aluminum hydride2,3 or borane¨Ctetrahydrofuran(eq 1); (b) from the hydroboration/oxidation or oxymercuration/demercuration of vinyltrimethylsilane (eq 2); and (c)most conveniently, by the reaction of the Grignard reagent
formed from (chloromethyl)trimethylsilane with paraformaldehyde
(eq 3).
l?uterung methode
If the NMR spectrum is not clean, then dissolve the alcohol in Et2O, wash it with aqueous NH4Cl solution, dry (Na2SO4), evaporate and distil it. The 3,4-dinitrobenzoyl derivative has m 66o (from EtOH). [NMR: Speier et al. J Am Chem Soc 79 974 1957, Z Naturforsch 14b 137 1959, Beilstein 4 IV 3951.]
2-(Trimethylsilyl)ethanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
