8-Chloroadenosine
8-Chloroadenosine ??
???
189-191 °C
?? ?
707.4±70.0 °C(Predicted)
??
2.19±0.1 g/cm3(Predicted)
?? ??
Sealed in dry,Store in freezer, under -20°C
???
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
?? ?? (pKa)
12.90±0.70(Predicted)
??? ??
??? ??.
??
White to off-white
InChI
InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
InChIKey
MHDPPLULTMGBSI-UUOKFMHZSA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2Cl)[C@H](O)[C@@H]1O
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H302 ??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H315 ??? ??? ???
????? ?? ?????
?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
??
P264, P280, P305+P351+P338,P337+P313P
H332 ???? ???
?? ?? ?? ??
?? 4
??
P261, P271, P304+P340, P312
H335 ?? ???? ??? ? ??
?? ???? ?? - 1? ??;???? ??
?? 3
??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
8-Chloroadenosine C??? ??, ??, ??
??
8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
8-Chloroadenosine ?? ?? ? ???
???
?? ??
8-Chloroadenosine ?? ??
???( 100)?? ??
China 81
Germany 2
India 3
Switzerland 1
United Kingdom 3
United States 10
Global 100
8-Chloroadenosine ?? ??:
?????
2-Chloroadenosine
8-Chloroadenosine
2-CHLOROADENOSINE HEMIHYDRATE,2-CHLOROADENOSINE HEMIDYDRATE
2-Amino-6-chloropurine Riboside
6-Chloropurine riboside
8-CHLOROADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT,8-chloroadenosine-5’-monophosphate(8-cl-5’-amp),freeaci
8-CHLOROADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT,8-chloroadenosine-5’-triphosphate(8-cl-atp),sodiumsal
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
8-CHLORO-CAMP
N-Cyclopentyl-2-chloroadenosine
2-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT,2-chloroadenosine-3’,5’-cyclicmonophosphate,sodiumsalt(2-cl-camp
2-Chloroadenosine 5’-Monophosphate
DIINOSINE PENTAPHOSPHATE
2-CHLOROADENOSINE, [8-14C]-
2-CHLOROADENOSINE-5'-CARBOXY-2',3'-ACETONIDE
L-2-CHLOROADENOSINE (9-(β-L-RIBOFURANOSYL)-2-CHLORO-6-AMINOPURINE)
