ChemicalBook >?? ???? >2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE

2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE

2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE ??? ???

?? ??:: 7057-48-9

???:: 2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE

???(??):: D4A;BETA-L-D4A;NSC 108602;Compound FL0097;Didanosin EP Imp I;Didanosine EP Impurity I;2',3'-Dideoxy-2'3'-didehy...;2'3'-didehydro-2'3'-dideoxyadenosine;2',3'-Dideoxy-2',3'-didehydroadenosine;Adenosine, 2',3'-didehydro-2',3'-dideoxy-

CBNumber:: CB5237586

???:: C10H11N5O2

??? ??:: 233.23

MOL ??:: 7057-48-9.mol

?? ?? 57

2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE ??

???: 187-189°C

?? ?: 553.9±60.0 °C(Predicted)

??: 1.74±0.1 g/cm3(Predicted)

?? ??: 2-8°C(protect from light)

???: DMSO? ???

?? ?? (pKa): 14.28±0.10(Predicted)

??: white solid

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??		P264, P270, P301+P312, P330, P501

??????:

P280	????/???/???/?????? ?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE C??? ??, ??, ??

??

2’,3’-Dideoxy-2,3-didehydroadenosine (Didanosine EP Impurity I) is an impurity of Didanosine (D440950), which is a purine analog (1) which used as an antiviral agent. Classed as an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction (2).

2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE ?? ?? ? ???

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?? ??

2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE ?? ??

???( 57)?? ??

???	??	???	??	?? ?	??
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2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE ?? ??:

???????(2,5-) 5'-DEOXYADENOSINE Dideoxyadenosine 2',3'-Anhydroinosine 2',3'-dideoxy-2',3'-didehydroadenosine monophosphate 3-BUTENE-1,2-DIOL 1-Allylimidazole 2-METHOXY-3-BUTEN-1-OL 3-BUTENE-1,2-DIOL 2',3'-DIDEOXY-2',3'-DIDEHYDROADENOSINE

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