ChemicalBook >?? ???? >MK-4827(????)
MK-4827(????)
|
|
MK-4827(????) ??
- ???
- >142oC (dec.)
- ?? ??
- -20°C Freezer
- ???
- ???(??)? ???
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ????? ?? ???
- InChIKey
- LCPFHXWLJMNKNC-XOIICWPPNA-N
- SMILES
- S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r|
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ?? ?: | Warning | |||||||||||||||||||||||||||||||||||
| ??·?? ??: |
|
|||||||||||||||||||||||||||||||||||
| ??????: |
|
MK-4827(????) C??? ??, ??, ??
??
Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.??
Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.MK-4827(????) ?? ?? ? ???
???
?? ??
MK-4827(????) ?? ??
???( 171)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +86-18701775035 |
market@hopelife.cn | China | 72 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 |
nickzhang@hangyubiotech.com | China | 9935 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1796 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32998 | 60 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 |
sales@tianpharm.com | CHINA | 304 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19935 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 |
sales04@yibaibiotech.com | CHINA | 416 | 58 |
| CONIER CHEM AND PHARMA LIMITED | |
sales@conier.com | China | 49906 | 58 |
| career henan chemical co | +86-0371-86658258 |
factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 |
MK-4827(????) ?? ??:
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
Ruxolitinib phosphate
Nintedanib
Triethyl orthoformate
Tosyl azide
EGF816 (mesylate)
Epacadostat (INCB024360)
Nintedanib Ethanesulfonate Salt
MK-4827 (R-enantioMer)
AnaMorelin hydrochloride
BKM120 (NVP-BKM120, Buparlisib)
tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate
Niraparib
Niraparib tosylate
3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester