ChemicalBook >?? ???? >??????
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?????? ??
- ???
- 128-130C
- ?? ?
- 456.71°C (rough estimate)
- ??
- 1.12
- ???
- 1.5180 (estimate)
- ?? ??
- 2-8°C
- ???
- DMSO: >10mg/mL
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 6.46±0.40(Predicted)
- ??
- ???
- Merck
- 14,9182
- BRN
- 40090
- ???
- ??? ?? ?????? 1? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 1?? ?? ??? ? ????.
- InChI
- InChI=1/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/s3
- InChIKey
- MKJIEFSOBYUXJB-UHFFFAOYSA-N
- SMILES
- C12=CC(OC)=C(OC)C=C1CCN1[C@]2([H])CC(=O)[C@H](CC(C)C)C1 |&1:13,18,r|
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22 | ||
| ????? | 24/25 | ||
| ????(UN No.) | 3249 | ||
| WGK ?? | 3 | ||
| RTECS ?? | DK2275000 | ||
| ?? ?? | 6.1(b) | ||
| ???? | III | ||
| HS ?? | 29339900 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral | ||
| ?? ?? ??? | 58-46-8(Hazardous Substances Data) |
?????? C??? ??, ??, ??
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White to Off-White Solid??
Tetrabenazine has been used for dopamine uptake assays in mouse brain cells1. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells2.??
ChEBI: A benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 an 7.?? ??
A cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.???? ??
Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC 50 = 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.Purification Methods
Crystallise it from MeOH. The hydrochloride has m 208-210o, and the oxime has m 158o (from EtOH). [Beilstein 21 III/IV 6488.]?????? ?? ?? ? ???
???
7-???-1,2,3,4-??????-????????
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
1,2,3,4-???????????
(2-???-4-????)????????????
6,7-Dimethoxy-3,4-dihydroisoquinoline
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?????? ?? ??
???( 263)?? ??
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|---|---|---|---|---|---|
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?????? ?? ??:
??(1-)-4-????
1-(3-METHOXY-PHENYL)-ETHYLAMINE
1-Phenethyl-4-piperidone
N-Methylhomoveratrylamine
1-Ethyl-4-piperidone
Salsoline
Tetrabenazine
2-Methyl-4-piperidone
1-Propyl-4-piperidone
Tetrabenazine metabolite A,Tetrabenazine metabolite B
2H-BENZO[A]QUINOLIZIN-2-ONE, 1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-, (3S,11BS)-
CHEMBRDG-BB 4014220
6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE
1-PHENYL-BUTYLAMINE
AKOS BC-3154
1-(4-METHOXY-PHENYL)-PROPYLAMINE
Isoquinoline, 1,2,3,4-tetrahydro-2-methyl-
Benzenepentanamine