2-Chloro-5-fluoropyrimidine
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2-Chloro-5-fluoropyrimidine ??
- ?? ?
- 149.0-162.0°C
- ??
- 1.439 g/mL at 20 °C (lit.)
- ???
- n
20/D 1.503(lit.)
- ???
- 150 °F
- ?? ??
- under inert gas (nitrogen or Argon) at 2-8°C
- ?? ?? (pKa)
- -2.54±0.22(Predicted)
- ??? ??
- ??
- ??
- ??~???? ???
- InChI
- InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
- InChIKey
- AGYUQBNABXVWMS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(F)C=N1
- CAS ??????
- 62802-42-0(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 22-34-41-37/38 | ||
| ????? | 26-36/37/39-45 | ||
| ????(UN No.) | UN 2735 8/PG 2 | ||
| WGK ?? | 3 | ||
| ?? ?? ?? | Harmful | ||
| ?? ?? | IRRITANT | ||
| ?? ?? | 8 | ||
| ???? | Ⅲ | ||
| HS ?? | 29335990 | ||
| ???? ??? | 8A - Combustible corrosive hazardous materials | ||
| Hazard Classifications | Acute Tox. 4 Oral Skin Corr. 1B |
2-Chloro-5-fluoropyrimidine C??? ??, ??, ??
??? ??
Colorless to light yellow liquid??
2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.?? ??
Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.?? ??
[1] A. Dunaiskis. “LARGE SCALE SYNTHESIS OF 2-CHLORO-5-FLUOROPYRIMIDINE.” Organic Preparations and Procedures International 27 1 (1995): 600–602.[2] A. DUNAISKIS. “ChemInform Abstract: Large Scale Synthesis of 2-Chloro-5-fluoropyrimidine.” ChemInform 26 52 (1995).
2-Chloro-5-fluoropyrimidine ?? ?? ? ???
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?? ??
2-Chloro-5-fluoropyrimidine ?? ??
???( 381)?? ??
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2-Chloro-5-fluoropyrimidine ?? ??:
LAMBDACYHALOTHRIN ???? ????? ??????????
5-Fluoropyrimidine
2-Chloropyrimidine
2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE
2,4-DICHLORO-6-ETHYL-5-FLUOROPYRIMIDINE
4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE,4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE GC 95.0%,2-Chloro-5-fluoropyrimidine-4-amine
2,4-Dichloro-5-fluoropyrimidine
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine
Pyrimidine, 4-chloro-6-fluoro- (9CI)
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
2-Fluoro-3,5-dichloropyridine
4,6-Dichloro-5-fluoropyrimidine
3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride
4-(1-bromoethyl)-6-chloro-5-fluoropyrimidine
CHEMBRDG-BB 4015094