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1400W

1400W ??? ???
?? ??:
180001-34-7
???:
1400W
???(??):
1400W DIHYDROCHLORIDE;N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE;400W;1400W;W 1400;N-(3-(aminomethyl)benzyl)acetimidamide;N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL;Ethanimidamide, N-[[3-(aminomethyl)phenyl]methyl]-;N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE;N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE
CBNumber:
CB5343313
???:
C10H15N3
??? ??:
177.25
MOL ??:
180001-34-7.mol

1400W ??

???
208-220 °C
?? ?
301.7±44.0 °C(Predicted)
??
1.09±0.1 g/cm3(Predicted)
?? ??
−20°C
???
DMSO, ???, ?? ???
?? ?? (pKa)
11.33±0.50(Predicted)
??? ??
??
??? ??
??? ??
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??

????? 22-24/25
WGK ?? 3

1400W C??? ??, ??, ??

??? ??

White Solid

??

1400W selectively inhibits inducible nitric oxide synthase. W 1400 has been implicated to prevent Doxorubicin and Trastuzumab induced cardiotoxicity.

???? ??

Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (K d = 7 nM). Selective over nNOS and eNOS (K i values are 2 and 50 μ M respectively). Cell-permeable and active in vivo .

1400W ?? ?? ? ???

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1400W ?? ??

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