ChemicalBook >?? ???? >L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE ??
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- -20°C
- ???
- DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
- ??? ??
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- synthetic (organic)
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- water: 50mg/mL, clear, colorless
- InChI
- 1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
- InChIKey
- OQIBCXRAFAHXMM-KLXURFKVSA-N
- SMILES
- Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
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- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38 | ||
| ????? | 37/39-26-36 | ||
| WGK ?? | 3 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE C??? ??, ??, ??
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L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.??
L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:- to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
Biochem/physiol Actions
Selective inhibitor of inducible nitric oxide synthase (iNOS).L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE ?? ?? ? ???
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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE ?? ??:
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