ChemicalBook >?? ???? >1,5-???????

1,5-???????

1,5-??????? ??? ???

?? ??:: 5154-02-9

???:: 1,5-???????

???(??):: 1,5-???????

???:: 1,5-ISOQUINOLINEDIOL

???(??):: DHQ;DIQ;NSC 65585;1,5-ISOQUINOLINEDIOL;isoquinoline-1,5-diol;PARP Inhibitor IV, IQD;5-HYDROXYISOCARBOSTYRIL;1,5-Isoquinolinediol,98%;5-Hydroxy-isoquinolinone;1,5-Isoquinolinediol ,97%

CBNumber:: CB5360303

???:: C9H7NO2

??? ??:: 161.16

MOL ??:: 5154-02-9.mol

MSDS ??:: SDS

?? ?? 128

1,5-??????? ??

???: 270-275 °C

?? ?: 287.44°C (rough estimate)

??: 1.2480 (rough estimate)

???: 1.5050 (estimate)

?? ??: Keep in dark place,Sealed in dry,Room Temperature

???: DMSO: >36mg/mL

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 8.52±0.20(Predicted)

??: ???

InChI: InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)

InChIKey: LFUJIPVWTMGYDG-UHFFFAOYSA-N

SMILES: C1(=O)C2=C(C(O)=CC=C2)C=CN1

CAS ??????: 5154-02-9(CAS DataBase Reference)

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	Xi
?? ???? ??	36/37/38
?????	26-37/39
WGK ??	3
HS ??	29337900
???? ???	11 - Combustible Solids

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P233	??? ??? ?????. ??? ??? ? ?? ?? ??? ???? ?????.
P260	??·?·??·???·??·...·????? ???? ???.
P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P271	?? ?? ??? ? ?? ???? ?????.
P280	????/???/???/?????? ?????.
P302+P352	??? ??? ??? ?? ????.
P304	???? ???? ??? ????(??)? ??? ????
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P312	???? ??? ????(??)? ??? ????.
P321	(…) ??? ???.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.
P340	??? ??, ??, ???? ?? ??? ???
P362	??? ??? ?? ?? ?? ?????
P403	??? ? ?? ?? ?????.
P403+P233	??? ??? ? ?? ?? ??? ???? ?????.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
2		0

1,5-??????? C??? ??, ??, ??

??

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

??? ??

white to off-white solid

??

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

??

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

?? ??

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

1,5-??????? ?? ?? ? ???

???

?? ??

ethyl 2-[(1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate

1,5-??????? ?? ??

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1,5-??????? ?? ??:

??????? ????? ??? ????? 1-???????? 1,5-ISOQUINOLINEDIOL 1,2,3,4-TETRAHYDRO-1-METHYL-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-Tetrahydro-1-methyl-6,7-Isoquinolinediol 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methyl-6,7-isoquinolinediol 5-Hydroxyisoquinoline 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE 98% 1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol Tretoquinol (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride 5-METHOXY-2H-ISOQUINOLIN-1-ONE 6,7-Isoquinolinediol, 1-propyl- (9CI) d-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 6,7-Isoquinolinediol, 1-(1-methylethyl)- (9CI) 6,7-Isoquinolinediol, 1-[(1S)-1,2-dihydroxyethyl]-1,2,3,4-tetrahydro- (9CI) 3,4-Dihydro-6,7-isoquinolinediol. Tretoquinol hydrochloride

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